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中国真菌学杂志 2014, Vol. 9  Issue (3): 182-185.

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新生隐球菌嗜中枢性感染机制的研究进展

法振宗, 方伟, 顾菊林, 廖万清   

  1. 上海长征医院皮肤病与真菌病研究所 全军真菌病重点实验室 第二军医大学附属长征医院皮肤科, 上海 200003
  • 收稿日期:2014-03-06 出版日期:2014-06-28 发布日期:2014-06-28
  • 通讯作者: 廖万清,E-mail:liaowanqing@sohu.com;顾菊林,E-mail:wujgjl@126.com E-mail:liaowanqing@sohu.com;wujgjl@126.com
  • 作者简介:法振宗,男(汉族),硕士研究生在读.E-mail:fazhenzong@163.com
  • 基金资助:

    973项目(2013CB531601);国家自然基金(81271799);上海科委项目(10dz2220100,12JC141000)

Advances in Neurotropism of Cryptococcus neoformans

FA Zhen-Zong, FANG Wei, GU Ju-Lin, LIAO Wan-Qing   

  1. Department of dermatology, Changzheng Hospital, Institute of dermatology and medical mycology, Changzheng Hospital, Key laboratory of molecular medical mycology, PLA key laboratory of medical mycology, Shanghai 200003
  • Received:2014-03-06 Online:2014-06-28 Published:2014-06-28

摘要:

新生隐球菌是临床上最重要的侵袭性病原真菌之一,可感染免疫抑制和免疫正常人群引发具有致命威胁的隐球菌性脑膜脑炎。近年来,隐球菌嗜中枢神经系统感染的机制研究取得了长足的进展,隐球菌参与侵袭中枢神经系统的相关毒力因子及多条宿主细胞应答信号通路相继被发现。

关键词: 新生隐球菌, 中枢神经系统感染, 病原宿主相互作用, 毒力因子

Abstract:

Cryptococcus neoformans is a kind of opportunistic fungal pathogen which has a predilection for the central nervous system, resulting in devastating meningoencephalitis. In recent years,the study of the mechanism of Neurotropism of Cryptococcus neoformans has made a great progress. Many violence factors of this pathogen and several signing pathways of the host involved in this process have been discovered.

Key words: Cryptococcus neoformans, central nervous system infections, host-pathogen interactions, virulence factors

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