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中国真菌学杂志 2012, Vol. 7  Issue (6): 359-361.

病例报告 上一篇    下一篇

面部念珠菌性肉芽肿1例

朱文静1, 李雪1, 张旭焱2, 牟妍1, 金仙花1, 于凯1, 李福秋1, 夏建新1   

  1. 1. 吉林大学第二医院皮肤科,长春 130041;
    2. 内蒙古兴安盟蒙医院皮肤科,乌兰浩特 137400
  • 收稿日期:2012-08-03 出版日期:2012-12-28 发布日期:2012-12-28
  • 通讯作者: 夏建新 E-mail:xiajx@jlu.edu.cn
  • 作者简介:朱文静,女 (汉族),硕士研究生在读.E-mail:zhuzhu2584@sina.com

A case of facial skin candidal granuloma

ZHU Wen-jing1, LI Xue1, ZHANG Xu-yan2, MU Yan1, JIN Xian-hua1, YU Kai1, LI Fu-qiu1, XIA Jian-xin1   

  1. 1. Department of Dermatology,Second Hospital of Jilin University,Changchun 130041,China;
    2. Department of Dermatology,Mongolian Hospital of Inner Mongolia Xinganmeng County,Ulanhot 137400,China
  • Received:2012-08-03 Online:2012-12-28 Published:2012-12-28

摘要:

报道1例面部皮肤念珠菌性肉芽肿。患者女,14岁,口角糜烂10 a, 面部散在斑块、结痂6 a。表现为面部大小不等圆形暗红色斑块,表面见黄褐色厚痂。额部皮损真菌镜检见大量菌丝,真菌培养鉴定为白念珠菌。组织病理见真皮浅中层弥漫性淋巴细胞、少量中性粒细胞浸润,并见多核巨细胞。PAS染色示角质层及痂皮内见大量菌丝,真皮多核巨细胞内见孢子。诊断为念珠菌性肉芽肿。给予灰黄霉素治疗2个月、卡介菌多糖核酸治疗6个月、伊曲康唑治疗7个月后,皮损减少,面部痂皮大部分脱落,目前仍在治疗中。

关键词: 肉芽肿, 念珠菌, 白念珠菌, 伊曲康唑

Abstract:

A case of facial skin candidal granuloma was reported.A 14-year-old girl had a history of erosion around mouth for 10 years and interspersed plaques,scab on face for six years.Physical examination showed dark-red plaques with tan thick scab of various sizes on her face. Fungal microscope examination showed mass hyphae and that was identified as Candidas albicans.Histopathological examination revealed infiltration of diffuse lymphocytes,sparse neutrophils and multinucleated giant cells in upper dermis.Mass hyphae was found in cuticle and spores were found in multinucleated giant cells by PAS stain.The diagnosis was made as candidal granuloma.The lesions improved after treatment of two-month with Griseofulvin,six-month with BCG-PSN,seven-month with Itraconazole, most of the scab was dropped. The patient is still under treatment.

Key words: granuloma, Candida, Candida albicans, itraconazole

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