关键词: 新生隐球菌, CD44, 隐球菌性脑膜炎

Abstract: Objective To determine the CD44 expression in the brain of mice with cryptococcal meningitis and to explore its role in pathogenesis of cryptococcal meningitis.Methods CD44 expression in immunocompromised mice with or without cryptococcal meningitis were determined at 6 h,12 h,24 h,48 h,72 h,4 d,7 d by immunohistochemistry.Results CD44 distributed uniformly in the brain cell membrane in the control group.The expression increased in the meningeal side,while decreased significantly in the parenchyma side after 48 h and 72 h in the experimental group.This unbalanced distribution of CD44 expression was also observed around lesions.Conclusions Cryptococcus neoformans could induce CD44 migration in the brain.The incidence of cryptococcal meningitis has effects on CD44 molecules.

Key words: Cryptococcus neoformans, cryptococcal meningitis, CD44