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中国真菌学杂志 2011, Vol. 6  Issue (2): 98-100.

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8种中药单体抗球形马拉色菌的体外药敏实验

黄欣1, 沈亮亮1, 徐红2, 温海2   

  1. 1. 同济大学附属同济医院皮肤科, 上海, 200065;
    2. 第二军医大学长征医院皮肤科, 上海, 200003
  • 收稿日期:2011-02-10 出版日期:2011-04-28 发布日期:2011-04-28
  • 通讯作者: 温海,E-mail:wenhai98@sohu.com E-mail:wenhai98@sohu.com
  • 作者简介:黄欣,女(汉族),博士,副主任医师.E-mail:alida_huang@yahoo.com.cn
  • 基金资助:
    上海市卫生局青年科研基金(2006Y53)

Inhibition of eight Chineseherbal components on M.globosa in vitro

HUANG Xin1, SHEN Liang-liang1, XU Hong2, WEN Hai2   

  1. 1. Department of Dermatology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065;
    2. Department of Dermatology, Changzheng Hospital, Second Military Medical Univercity, Shanghai, 200003
  • Received:2011-02-10 Online:2011-04-28 Published:2011-04-28

摘要: 目的 观察8种中药单体对球形马拉色菌的体外抑菌效果。方法 参照美国临床和实验室标准化研究所(CLSI)制订的M27-A方案中酵母菌微量稀释法,测定各中药单体体外抗球形马拉色菌的敏感性。结果 8种中药单体中,苦参碱、氧化苦参碱、麝香草酚、丁香酚有较强的抗马拉色菌作用(MIC<0.98-1.96μg/mL)。结论 苦参碱、氧化苦参碱、麝香草酚、丁香酚有较强的抗马拉色菌作用,CLSI-M27A方案可用于抗马拉色菌敏感性测定。

关键词: 中药单体, 马拉色菌, 最小抑菌浓度

Abstract: Objective To observe the in vitro inhibitive effect of eight kind of Chineseherbal components on ATCC standard strains of M.globosa.Methods The sensitivities of Chineseherbal components to M.globosa were determined on the basis of Clinical and Laboratory Standards Institute M27-A microdilution method.Results The MICs of Matrine,Oxymatrine,thymol and Eugenol were less than 0.98 to 1.96 μg/mL.Conclusions Matrine,Oxymatrine,thymol and Eugenolhave inhibitive effects on Malassezia in vitro and the susceptibilities could be determined by CLSI M27-A scheme.

Key words: Chineseherbal components, Malassezia, Minimum inhibitive sensitivity

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