关键词: 马尔尼菲青霉病, 死亡, 危险因素

Abstract: Objective To explore the death risk factors of Penicillium marneffei(PM) infection in AIDS patients for death risks reducing and prognosis improvement.Methods A total of 101 AIDS cases complicated with Penicilliosis marneffei(PSM) who had been hospitalized in our hospital between 2007 and 2010 were involved and divided into death group and survival group,according to prognosis.Indexes including age,sex,fever,periumbilical concave rash,bellyache,dyspnea,gastrointestinal hemorrhage,bacterial septicemia,the counts of WBC,HGB,PLT,CR,ALT,AST,T.BIL,absolute counting of CD4+ T lymphocytes,triglycerides,the time of positive fungus cultivation,beginning time of effctive antifungal therapy,regimen of antimycotic therapy,HAART(High active anti-retroviral therapy)accepted or not were compared and statistical analysis was carried out.Results Abdominal pain,dyspnea,gastrointestinal hemorrhage,peritoneal irritation sign,the counts of WBC,Cr,T.BIL,AST,CD4+ acounts,triglycerides,positive fungal culture time between two groups showed statistical significance(P< 0.05).The ORs of peritoneal irritation sign,dyspnea and WBC counting increasing in multivariate logistic regression were 226.733,90.213 and 2.216 respectively.The OR of elevated Cr was 1.014.Conclusions The peritoneal irritation sign,dyspnea,hoist of WBC counting,elevated Cr were the main death risk factors in AIDS patients complicated with PSM.Treatment of the complication may be helpful for mortality decreasing.

Key words: Penicilliosis marneffei, death, risk factors