Fonsecaea monophora致皮肤着色芽生菌病1例

中国真菌学杂志　 2023, Vol. 18 　Issue (3): 250-253.

Fonsecaea monophora致皮肤着色芽生菌病1例

马珊珊¹, 李进¹, 鲁卫平¹, 黄庆¹, 雷霞², 黎敏¹

1. 陆军军医大学大坪医院检验科, 重庆 400042;
2. 陆军军医大学大坪医院皮肤科, 重庆 400042

收稿日期:2022-09-13 出版日期:2023-06-28 发布日期:2023-07-08
通讯作者: 黎敏,E-mail:minli011224@163.com E-mail:minli011224@163.com
作者简介:马珊珊,女(汉族),本科,主管技师.E-mail:1079037584@qq.com
基金资助:
陆军特色医学中心人才创新能力培养计划(项目编号:2019CXJSB005)

A case of chromoblastomycosis caused by Fonsecaea monophora

MA Shanshan¹, LI Jin¹, LU Weiping¹, HUANG Qing¹, LEI Xia², LI Min¹

1. Department of Clinical Laboratory, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing 40042, China;
2. Department of Dermatology and Cosmetology, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing 40042, China

Received:2022-09-13 Online:2023-06-28 Published:2023-07-08

摘要/Abstract

摘要： 报告重庆地区1例由Fonsecaea monophora感染引起的皮肤着色芽生菌病。患者,男,81岁,因左上臂内侧皮肤被铁片划伤后出现溃疡伴疼痛1年余到我院就诊。对患者皮损组织行组织病理学检查和真菌培养,将培养出的菌落做形态学和分子生物学鉴定。真菌培养获得菌落形态,小培养乳酸酚棉兰染色得到镜下特征形态,菌落形态:可见暗棕色和黑色菌落生长;镜下形态:可见枝孢型和喙枝孢型产孢;皮损处组织病理学检查结果:可见慢性肉芽肿样改变。ITS( internal transcribed spacer)区域测序鉴定结果为Fonsecaea monophora。根据实验室培养结果和临床资料分析确定该例为Fonsecaea monophora感染引起的着色芽生菌病。口服伊曲康唑200 mg,2次/日,联合药物涂抹和光动力学治疗有效。

关键词: Fonsecaea monophora, 着色芽生菌病, ITS区域测序, 伊曲康唑

Abstract: To report a case of chromoblastomycosis caused by Fonsecaea monophora in Chongqing. An 81-year-old male patient came to our hospital with ulcer and pain for more than one year after the skin on the inner side of his left upper arm was cut by an iron piece. Histopathological examination and fungal culture were performed on the skin lesions of the patients, and the cultured colonies were identified by morphology and molecular biology methods. Colony morphology: dark brown and black colonies were observed. Microscopically, cladosporium and rostrum sporulation were observed. Histopathological examination of the lesions showed chronic granulomatous changes. Sequencing of the internal transcribed spacer (ITS) region was identified as Fonsecaea monophora. According to the laboratory culture results and clinical data analysis, this case was identified as chromoblastomycosis caused by Fonsecaea monophora. Oral itraconazole 200mg twice a day, combined with drug application topically and photodynamic therapy was effective.

Key words: Fonsecaea monophora, chromoblastomycosis, ITS region sequencing, itraconazole

中图分类号:

R 519.2

马珊珊, 李进, 鲁卫平, 黄庆, 雷霞, 黎敏. Fonsecaea monophora致皮肤着色芽生菌病1例[J]. 中国真菌学杂志, 2023, 18(3): 250-253.

MA Shanshan, LI Jin, LU Weiping, HUANG Qing, LEI Xia, LI Min. A case of chromoblastomycosis caused by Fonsecaea monophora[J]. Chinese Journal of Mycology, 2023, 18(3): 250-253.

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