非HIV马尔尼菲篮状菌病免疫相关易感因素分析

中国真菌学杂志　 2023, Vol. 18 　Issue (2): 97-103,110.

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非HIV马尔尼菲篮状菌病免疫相关易感因素分析

李恬恬, 李炳坤, 黄晓露, 廖柳维, 蒋志文, 何小娟, 莫南芳, 李秀楹, 蒋丽, 潘开素, 曹存巍

广西医科大学第一附属医院皮肤性病科, 南宁 530000

收稿日期:2022-09-16 出版日期:2023-04-28 发布日期:2023-05-26
通讯作者: 曹存巍,E-mail:caocunwei@yeah.net E-mail:caocunwei@yeah.net
作者简介:李恬恬,女(壮族),硕士研究生在读.E-mail:mandylttgxmu@163.com
基金资助:
国家自然科学基金(82173433);广西创新研究团队(2020GXNSFGA238001);广西医科大学第一附属医院重点实验室培育计划(YYZS2020006)

Analysis of susceptibility factors forinfection with Talaromyces marneffei in non-HIV individuals

LI Tiantian, LI Bingkun, HUANG Xiaolu, LIAO Liuwei, JIANG Zhiwen, HE Xiaojuan, MO Nanfang, LI Xiuying, JIANG Li, PAN Kaisu, CAO Cunwei

Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanjing 530000, China

Received:2022-09-16 Online:2023-04-28 Published:2023-05-26

摘要/Abstract

摘要： 目的对HIV阴性的马尔尼菲篮状菌病(TSM)患者的免疫相关易感因素进行分析,以提高临床医师对这一疾病的认识和管理。方法前瞻性研究本课题组收集的来自广西及国内其他省市2012年至2021年确诊为HIV阴性的TSM患者临床特点,分析其免疫相关易感因素。结果纳入患者154例,132例检出免疫缺陷。儿童患者以原发性免疫缺陷病为主;成人患者以抗伽马干扰素自身抗体相关的免疫缺陷综合征为主,其余包括合并恶性肿瘤及结缔组织病等基础病。结论 TSM可发生于存在不同形式免疫缺陷的非HIV患者,应基于易感因素建立完整的免疫状态评估策略,以改善患者预后。

关键词: 马尔尼菲篮状菌, HIV阴性, 原发性免疫缺陷, 抗伽马干扰素自身抗体

Abstract: Objective To analyze the immune-related susceptibility factors of Talaromyces marneffei infection (TSM) in non-HIV patients, so as to improve the understanding and management of this disease among clinicians. Methods The clinical characteristics of HIV-negative patients diagnosed with TSM from 2012 to 2021 in Guangxi and other provinces and cities in China collected by our group were prospectively studied to analyse their immune-related susceptibility factors. Results 154 patients were included, and immunodeficiency was detected in 132 cases. Primary immunodeficiency diseases predominated in pediatric patients; immunodeficiency syndrome associated with anti-interferon-gamma autoantibodies predominated in adult patients, and the remainder included co-morbid malignancies and underlying diseases such as connective tissue disease. Conclusion TSM can occur in non-HIV patients with different forms of immunodeficiency and a complete immune status assessment strategy based on susceptibility factors should be established to improve patient prognosis.

Key words: Talaromyce marneffei, HIV-negative, primary immunodeficiency, anti-interferon-gamma autoantibodies

中图分类号:

R519.8

李恬恬, 李炳坤, 黄晓露, 廖柳维, 蒋志文, 何小娟, 莫南芳, 李秀楹, 蒋丽, 潘开素, 曹存巍. 非HIV马尔尼菲篮状菌病免疫相关易感因素分析[J]. 中国真菌学杂志, 2023, 18(2): 97-103,110.

LI Tiantian, LI Bingkun, HUANG Xiaolu, LIAO Liuwei, JIANG Zhiwen, HE Xiaojuan, MO Nanfang, LI Xiuying, JIANG Li, PAN Kaisu, CAO Cunwei. Analysis of susceptibility factors forinfection with Talaromyces marneffei in non-HIV individuals[J]. Chinese Journal of Mycology, 2023, 18(2): 97-103,110.

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非HIV马尔尼菲篮状菌病免疫相关易感因素分析

Analysis of susceptibility factors forinfection with Talaromyces marneffei in non-HIV individuals

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