马尔尼菲篮状菌致HIV阴性患者眼睑脓肿1例

中国真菌学杂志　 2023, Vol. 18 　Issue (2): 156-159.

马尔尼菲篮状菌致HIV阴性患者眼睑脓肿1例

胡琴¹, 吴琼², 欧阳奕³

1. 中南大学湘雅医院药学部, 长沙 410008;
2. 中南大学湘雅医院检验科, 长沙 410008;
3. 中南大学湘雅医院感染病科, 长沙 410008

收稿日期:2022-02-21 出版日期:2023-04-28 发布日期:2023-05-26
通讯作者: 欧阳奕,E-mail:chuyi_1993@163.com E-mail:chuyi_1993@163.com
作者简介:胡琴,女(汉族),硕士,主管药师.E-mail:huqin2016@csu.edu.cn
基金资助:
湖南省自然科学基金项目(2022JJ80045)

A case of eyelid abscess caused by Talaromyces marneffei in non-HIV patient

HU Qin¹, WU Qiong², OUYANG Yi³

1. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China;
2. Department of Laboratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China;
3. Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China

Received:2022-02-21 Online:2023-04-28 Published:2023-05-26

摘要/Abstract

摘要： 患者,女,43岁,发现颈部多发淋巴结肿大11个月,取淋巴结活检后诊断为"淋巴结核",抗结核治疗期间患者左上眼睑出现肿胀,行"左眼眼眶肿物摘除术(前路开眶)+带蒂皮瓣移植术",术后脓液培养示:马尔尼菲篮状菌,初始予两性霉素B治疗,后因肌酐升高改为口服伊曲康唑200 mg,2次/天,治疗7周后好转出院。院外口服伊曲康唑200 mg,2次/天,6个月后续以200 mg,1次/天,治疗8个月,随访两年未复发。

关键词: 马尔尼菲篮状菌, HIV阴性, 两性霉素B, 伊曲康唑, 眼睑脓肿

Abstract: A 43-year-old woman was found to have multiple swollen lymph nodes in the neck with a 11-month history. After taking a lymph node biopsy, she was diagnosed as "lymphatic tuberculosis." During anti-tuberculosis treatment, the patient experienced swelling of the upper left eyelid. She received "mass removal (anterior opening of the orbit) + pedicle flap transplantation", postoperative pus culture showed: Talaromyces marneffei. Treatment with intravenous amphotericin B was initiated, and later changed to itraconazole 200 mg twice-daily orally due to increased creatinine. The patient was discharged after totally 7 weeks treatment. Oral itraconazole 200 mg twice-daily was continued for 6 months followed by 200mg qd for 8 months, and there was no recurrence during a two-year follow-up.

Key words: Talaromyces marneffei, non -HIV patient, amphotericin B, itraconazole, ocular abscess

中图分类号:

R519.8

胡琴, 吴琼, 欧阳奕. 马尔尼菲篮状菌致HIV阴性患者眼睑脓肿1例[J]. 中国真菌学杂志, 2023, 18(2): 156-159.

HU Qin, WU Qiong, OUYANG Yi. A case of eyelid abscess caused by Talaromyces marneffei in non-HIV patient[J]. Chinese Journal of Mycology, 2023, 18(2): 156-159.

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