肺普通裂褶菌感染并肺不张1例并文献复习

中国真菌学杂志　 2023, Vol. 18 　Issue (2): 151-155.

肺普通裂褶菌感染并肺不张1例并文献复习

叶景焕¹, 陈珠妮¹, 刘玉², 李亚清², 谢纬²

1. 广州中医药大学第四临床医学院, 518033 深圳;
2. 深圳市中医院呼吸与危重症医学科, 518033 深圳

收稿日期:2022-02-21 出版日期:2023-04-28 发布日期:2023-05-26
通讯作者: 谢纬,E-mail:xiew0703@163.com E-mail:xiew0703@163.com
作者简介:叶景焕,男(汉族),硕士研究生在读.E-mail:13265025021@163.com
基金资助:
国家自然科学基金(81904103);深圳市"医疗卫生三名工程"项目(SZSM201812063)

Pulmonary infection caused by Schizophyllum commune complicated with atelectasis: a case report and review of the literature

YE Jinghuan¹, CHEN Zhuni¹, LIU Yu², LI Yaqing², XIE Wei²

1. Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China;
2. Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen 518033, China

Received:2022-02-21 Online:2023-04-28 Published:2023-05-26

摘要/Abstract

摘要： 普通裂褶菌(Schizophyllum commune, S. commune)是一种丝状真菌,为条件致病菌,引起人深部侵袭性感染国内报道罕见。我院收治了1例免疫功能正常患者肺部感染S. commune,广东人,既往体健,临床表现为反复出现的非刺激性咳嗽、咳黄白色黏液痰,胸部CT示右肺上叶肺不张并黏液栓,纤支镜下可见右肺上叶黏液栓堵塞及大量黄色脓性分泌物,肺泡灌洗液培养出S. commune,给予伊曲康唑抗真菌治疗1周后症状好转出院,出院后继续服用伊曲康唑3个月,随访复查胸部CT示病灶吸收,右肺上叶完全复张,提示抗真菌治疗有效。

关键词: 普通裂褶菌, 肺部感染, 肺不张, 纤支镜, 伊曲康唑

Abstract: Filamentous fungus Schizophyllum commune(S. commune) is a conditional pathogen. There were rare reports of S. commune caused deep invasive infection in human. A patient with pulmonary infection of S.commune with normal immune function was treated in our hospital, who came from Guangdong and presented recurrent non-irritating cough and yellowish-white mucus sputum. Computed tomography of the patient’s chest showed atelectasis with mucus thrombus in the upper lobe of the right lung. Fiberoptic bronchoscopy revealed that there was a mucinous embolus in the upper lobe of the right lung with massive yellow purulent discharge. Alveolar lavage fluid culture were positive for S. commune. His clinical status was improved and discharged after a week of itraconazole treatment. After being discharged from the hospital, the patient was maintained on itraconazole treatment for 3 months,computed tomography of the patient’s chest showed that the lesion was absorbed and the upper lobe of the right lung was completely dilated at his final follow-up, which suggested that the antifungal treatment was effective.

Key words: Schizophyllum commune, pulmonary infection, atelectasis, fiberoptic bronchoscopy, itraconazole

中图分类号:

R519.8

叶景焕, 陈珠妮, 刘玉, 李亚清, 谢纬. 肺普通裂褶菌感染并肺不张1例并文献复习[J]. 中国真菌学杂志, 2023, 18(2): 151-155.

YE Jinghuan, CHEN Zhuni, LIU Yu, LI Yaqing, XIE Wei. Pulmonary infection caused by Schizophyllum commune complicated with atelectasis: a case report and review of the literature[J]. Chinese Journal of Mycology, 2023, 18(2): 151-155.

参考文献

[1] 卯晓岚.中国大型真菌[M].郑州:河南科学技术出版社,2000:79.
[2] CHOWDHARY A, RANDHAWA H S, GAUR S N, et al. Schizophyllum commune as an emerging fungal pathogen:a review and report of two cases[J]. Mycoses, 2013,56(1):1-10.
[3] 郭敏,邓在春.裂褶菌相关肺部感染的研究进展[J].现代实用医学,2019,31(10):1416-1419.
[4] KLIGMAN A M.A basidiomycete probably causing onychomycosis[J].J Invest Dermatol,1950,14(1):67-70.
[5] KAMEI K, UNNO H, NAGAO K, et al. Allergic bronchopulmonary mycosis causedby the basidiomycetous fungus Schizophyllum commune[J]. Clin Infect Dis, 1994,18(3):305-309.
[6] RIHS J D, PADHYE A A, GOOD C B. Brain abscess caused by Schizophyllum commune:an emerging basidiomycete pathogen[J]. J Clin Microbiol, 1996, 34(7):1628-1632.
[7] HOENIGL M, ASPECK E, VALENTIN T, et al. Sinusitis and frontal brain abscess in a diabetic patient caused by the basidiomycete Schizophyllum commune:case report and review of the literature[J]. Mycoses,2013,56(3):389-393.
[8] CHAVES-BATISTA A, MAIA J A, SINGER R. Basidioneuromycosis on man[J]. An Soc Biol Pernambuco,1955,13(1):52-60.
[9] ZHU A, AN K R, CHEN Y, et al. A case of primary pulmonary Schizophyllum commune empyema treated with video-assisted thoracoscopic decortication[J].Gen Thorac Cardiovasc Surg,2021,69(3):584-587.
[10] SAHA S, SENGUPTA J, BANERJEE D, et al. Schizophyllum commune:a new organism in eye infection[J]. Mycopathologia,2013,175(3-4):357-360.
[11] RESTREPO A, GREER DL, ROBLEDO M, et al. Ulceration of the palate caused by a basidiomycete Schizophyllum commune[J]. Sabouraudia,1973,11(3):201-204.
[12] ROH M L, TUAZON C U, MANDLER R, et al. Sphenocavernous syndrome associated with Schizophyllum commune infection of the sphenoid sinus[J]. Ophthalmic Plast Reconstr Surg,2005,21(1):71-74.
[13] 沈凌,张维,祁明浩,等.肺部普通裂褶菌感染三例及文献复习[J].中华临床感染病杂志,2020,13(3):199-204.
[14] 刘颖梅,王春雷,李丽娟,等.普通裂褶菌引起的变应性支气管肺真菌病一例[J].中华结核和呼吸杂志,2018,41(2):145-146.
[15] 万力,林元珠,张金芳,等.普通裂褶菌所致变应性支气管肺真菌病一例[J].中华老年医学杂志,2011,30(12):1052-1053.
[16] 刘庆华,王成,胡芸倩,等.普通裂褶菌致肺部感染1例[J].中国真菌学杂志,2020,15(3):173-174.
[17] 李小梦,朱永泽,蒋露晰,等.裂褶菌引起的肺部真菌感染一例[J].中华临床医师杂志(电子版),2020,14(10):853-856.
[18] OGAWA H, FUJIMURA M, TAKEUCHI Y, et al. The definitive diagnostic processand successful treatment for ABPM caused by Schizophyllum commune:a report of two cases[J]. Allergol Int,2012,61(1):163-169.
[19] CHAN J F, TENG J L, LI I W, et al. Fatal empyema thoracis caused by Schizophyllum commune with cross-reactive cryptococcal antigenemia[J]. J Clin Microbiol,2014,52(2):683-687.
[20] 吴锐浩,陈栎江,徐春泉,等.裂褶菌感染引起变应性支气管肺真菌病1例[J].临床检验杂志,2017,35(10):798-800.
[21] SIGLER L, DE LA MAZA L M, TAN G, et al. Diagnostic difficulties caused by a nonclamped Schizophyllum commune isolate in a case of fungus ball of the lung[J]. J Clin Microbiol,1995,33(8):1979-1983.
[22] BUZINA W, LANG-LOIDOLT D, BRAUN H, et al. Development of molecular methods for identification of Schizophyllum commune from clinical samples[J]. J ClinMicrobiol,2001,39(7):2391-2396.
[23] CHOWDHARY A, AGARWAL K, KATHURIA S, et al. Allergic bronchopulmonary mycosis due to fungi other than Aspergillus:a global overview[J]. Crit Rev Microbiol,2014,40(1):30-48.
[24] DENNING D W, O'DRISCOLL B R, POWELL G, et al. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization:The Fungal Asthma Sensitization Trial (FAST) study[J]. Am J Respir Crit Care Med,2009,179(1):11-18.