马拉色菌菌丝阳性毛发型扁平苔癣1例

中国真菌学杂志　 2022, Vol. 17 　Issue (6): 500-502.

马拉色菌菌丝阳性毛发型扁平苔癣1例

李娟娟¹, 史冬梅²

1. 济宁医学院临床医学院, 济宁 272600;
2. 济宁市第一人民医院皮肤科医学真菌实验室, 济宁 272067

收稿日期:2021-09-06 发布日期:2023-01-04
通讯作者: 史冬梅,E-mail:shidongmei28@163.com E-mail:shidongmei28@163.com
作者简介:李娟娟,女(汉),硕士研究生在读,住院医师.E-mail:a13105815892@163.com
基金资助:
山东省中医药科技项目面上项目（NM2021M080）；山东省中医药科技项目面上项目（NM2021M080）

Positive Malassezia hyphae in lesions in one patient with lichen planopilaris

LI Juanjuan¹, SHI Dongmei²

1. Department of Clinical Medicine, Jining Medical University, Jining 272067, China;
2. Laboratory of Medical Mycology & Department of Dermatology, Jining No. 1 People's Hospital, Jining 272067, China

Received:2021-09-06 Published:2023-01-04

摘要/Abstract

摘要： 患者，男，14岁，头顶部出现红斑伴不规则脱发2年余，加重6个月。脱发区真菌免疫荧光显微镜检查：可见大量腊肠样菌丝及大量出芽孢子。真菌培养及分子生物学鉴定：球形马拉色菌。皮肤组织病理示：表皮网篮状角化；真皮浅层见噬黑素细胞，真皮深层可见胶原增生，炎细胞少见；毛囊结构消失。临床结合病理诊断：毛发扁平苔癣。口服伊曲康唑胶囊、外用酮康唑洗剂，2周后菌丝消失、孢子量减少，脱发症状减轻。

关键词: 毛发扁平苔藓, 永久性秃发, 瘢痕性脱发, 马拉色菌, 球形马拉色菌

Abstract: A 14-year-old male presented with erythema and irregular hair loss lesions on the scalp for over 2 years, aggravated for 6 months. A large number of sausages-like Malassezia hyphae were found under fungal fluorescence microscope. The isolate was identified as Malasseziaglobosa by ITS sequencing. Histopathological examination showed reticular keratosis of epidermis; the melanophagocytes were observed in the superficial dermis; the follicular units disappeared and sebaceous glands reduced in superficial and deep dermis; lymphocytes infiltrated around remaining subcutaneous appendages; collagen hyperplasia could be seen in the deep dermis. The diagnosis of lichen planopilaris was made based on the clinical and pathological feature. The patient was given oral itraconazole capsule combined with topical ketoconazole lotion. The hair loss stopped accompanied with the disappear of fungal hyphae after two weeks of treatment.

Key words: lichen planopilaris, permeant alopecia, cicatricial alopecia, Malassezia, Malassezia globose

中图分类号:

R 519.8 A

李娟娟, 史冬梅. 马拉色菌菌丝阳性毛发型扁平苔癣1例[J]. 中国真菌学杂志, 2022, 17(6): 500-502.

LI Juanjuan, SHI Dongmei. Positive Malassezia hyphae in lesions in one patient with lichen planopilaris[J]. Chinese Journal of Mycology, 2022, 17(6): 500-502.

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