盐酸特比萘芬乳膏联合3%硼酸酒精滴耳液治疗真菌性外耳道炎的效果

中国真菌学杂志　 2022, Vol. 17 　Issue (3): 227-230.

盐酸特比萘芬乳膏联合3%硼酸酒精滴耳液治疗真菌性外耳道炎的效果

杜昱聪, 刘环海

海军军医大学附属长征医院耳鼻咽喉科, 上海 200003

收稿日期:2021-09-15 出版日期:2022-06-28 发布日期:2022-07-02
通讯作者: 刘环海,E-mail:liuhuanhaiok@126.com E-mail:liuhuanhaiok@126.com
作者简介:杜昱聪,男(汉族),硕士研究生在读,住院医师.E-mail:475853338@qq.com
基金资助:
国家自然科学基金(81870702)

Effect of terbinafine hydrochloride cream combined with 3% boric acid alcohol ear drops on fungal otitis externa

DU Yucong, LIU Huanhai

Department of Otorhinolaryngology Head and Neck Surgery, Changzheng Hospital, Naval Medical University, Shanghai 200003, China

Received:2021-09-15 Online:2022-06-28 Published:2022-07-02

摘要/Abstract

摘要： 目的探究盐酸特比萘芬乳膏(terbinafine hydrochloride cream,THC)联合3%硼酸酒精(boric acid alcohol,BAA)滴耳液治疗真菌病的临床疗效。方法选取144例在我院治疗的真菌性外耳道炎患者作为研究对象,将患者随机分为A组和B组,A组采用3% BAA和THC联合治疗,B组单用BAA治疗。比较分析两组患者的治疗效果及真菌培养结果。结果 A组的治疗有效率及临床疗效评分明显优于B组(P<0.05);A组在瘙痒、耳溢、耳鸣这3个症状的改善较B组更明显(P<0.05);真菌培养中曲霉占57.7%,念珠菌占22.5%,并且对特比萘芬的敏感性高。结论 THS联合3%BAA滴耳液治疗真菌性外耳道炎的有效方法。

关键词: 特比萘芬, 硼酸, 真菌性外耳道炎

Abstract: Objective To explore the clinical efficacy of THC combined with 3% baa ear drops in the treatment of mycosis. Methods A total of 144 patients with external auditory canal mycosis treated in our hospital were enrolled. The patients were randomly divided into group A and group B. Group A was treated with 3% BAA and THC, and group B was treated with BAA alone. The therapeutic effects and fungal culture results of the two groups were compared and analyzed. Results The cure rate and clinical efficacy score of group A were significantly higher than those of group B (P<0.05); The improvement of pruritus, otorrhea and tinnitus in group A was more obvious than that in group B (P<0.05); Aspergillus and Candida accounted for 57.7% and 22.5% in the positive fungal culture, and they were highly sensitive to terbinafine. Conclusion THC combined with 3% baa ear drops is an effective method for the treatment of fungal otitis externa.

Key words: terbinafine, boric acid, fungal otitis externa

中图分类号:

R763

杜昱聪, 刘环海. 盐酸特比萘芬乳膏联合3%硼酸酒精滴耳液治疗真菌性外耳道炎的效果[J]. 中国真菌学杂志, 2022, 17(3): 227-230.

DU Yucong, LIU Huanhai. Effect of terbinafine hydrochloride cream combined with 3% boric acid alcohol ear drops on fungal otitis externa[J]. Chinese Journal of Mycology, 2022, 17(3): 227-230.

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