非HIV患者播散性马尔尼菲篮状菌感染并溶骨性破坏1例

中国真菌学杂志　 2021, Vol. 16 　Issue (6): 410-413.

病例报告上一篇

非HIV患者播散性马尔尼菲篮状菌感染并溶骨性破坏1例

黄春兰, 韦文飞, 马丽梅

柳州市人民医院检验科, 柳州 545001

收稿日期:2020-11-20 发布日期:2021-12-29
通讯作者: 马丽梅,E-mail:247637316@qq.com E-mail:247637316@qq.com
作者简介:黄春兰,女(汉族),硕士,副主任技师.E-mail:116845614@qq.com
基金资助:
广西壮族自治区卫生健康委员会重点实验室项目（ZZH2020004）；广西医科大学第一附属医院重点实验室培育项目（YYZS2020006）；广西卫健委自筹课题（Z2020084）

Osteolytic lesion caused by disseminated Talaromyce marneffei infection in a HIV negative patient

HUANG Chunlan, WEI Wenfei, MA Limei

Liu Zhou People's Hospital, Liuzhou 545001, China

Received:2020-11-20 Published:2021-12-29

摘要/Abstract

摘要： 马尔尼菲篮状菌(Talaromyce marneffei,T.marneffei)是一种温度依赖性双相真菌,HIV阴性患者感染播散性T.marneffei并溶骨性破坏国内报道少见,我院收治了1例非HIV患者感染播散性T.marneffei,广西人,既往体健,无免疫受损基础疾病,临床表现为发热、肩关节疼痛、体重下降、溶骨性破坏,HIV阴性,左肩关节脓液和外周静脉血均培养出T.marneffei,给予两性霉素B脂质体抗真菌治疗1个月后好转出院,但该患者出院后2年内又因其他原因住院3次,最后1次住院临床诊断为脓毒血症休克。该患者出院后6个月死亡,死亡原因很可能是鸟-胞内分枝杆菌合并马尔尼菲篮状菌感染。

关键词: 马尔尼菲篮状菌, HIV阴性, 溶骨性破坏

Abstract: Talaromyce marneffei(T.marneffei)is a dimorphic fungal.There were rare reports of T.marneffei caused osteolytic destruction in non-HIV-infected cases. A patient who came from Guangxi Zhuang Autonomous Region, presented with fever, shoulder pain, weight loss, osteolytie lesion. He was HIV-negative, physical health, and did not merge the underlying disease with immune impairment. Pus of left shoulder joint and blood culture were positive for T.marneffei, His clinical status was improved and discharged after a month of amphotericin B treatment. The patient had 3 readmissions for other reasons within 2 years later. The last admitting diagnosis was septic shock.He died 6 months later due to co-infection of Mycobacterium avium-intracellulare complex (MAC) and T.marneffei probably.

Key words: Talaromyces marneffei, HIV negative, osteolytic lesion

中图分类号:

R519.8

黄春兰, 韦文飞, 马丽梅. 非HIV患者播散性马尔尼菲篮状菌感染并溶骨性破坏1例[J]. 中国真菌学杂志, 2021, 16(6): 410-413.

HUANG Chunlan, WEI Wenfei, MA Limei. Osteolytic lesion caused by disseminated Talaromyce marneffei infection in a HIV negative patient[J]. Chinese Journal of Mycology, 2021, 16(6): 410-413.

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非HIV患者播散性马尔尼菲篮状菌感染并溶骨性破坏1例

Osteolytic lesion caused by disseminated Talaromyce marneffei infection in a HIV negative patient

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