Fonsecaea monophora所致海南渔民着色芽生菌病1例

中国真菌学杂志　 2021, Vol. 16 　Issue (3): 184-187.

Fonsecaea monophora所致海南渔民着色芽生菌病1例

牛牧¹, 廖万清², 吴伟伟¹, 郑文爱³

1. 海南省第五人民医院科室皮肤外科, 海口 571100;
2. 海军军医大学第二附属医院皮肤科, 上海 200003;
3. 海南省第五人民医院科室检验科, 海口 571100

收稿日期:2020-12-14 出版日期:2021-06-28 发布日期:2021-06-28
通讯作者: 廖万清,E-mail:liaowanqing@sohu.com E-mail:liaowanqing@sohu.com
作者简介:牛牧,男(汉族),硕士,主治医师.E-mail:382219948@qq.com

A case of Chromoblastomycosis caused by Fonsecaea monophora in Hainan fisherman

NIU Mu¹, LIAO Wanqing², WU Weiwei¹, ZHENG Wenai³

1. Department of Dermatologic surgery/Pathology, The fifth people's hospital of Hainan Province, Haikou 571101, China;
2. Department of Dermatology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China;
3. Department of Laboratory Medicine, The fifth people's hospital of hainan province, Haikou 571101, China

Received:2020-12-14 Online:2021-06-28 Published:2021-06-28

摘要/Abstract

摘要： 患者，男，80岁，渔民，捕鱼时右手腕关节擦伤后出现棕褐色结节11年。组织病理检查：慢性肉芽肿样改变，HE和PAS染色均可见到圆形、厚壁、棕色的硬壳小体。ITS区序列分析鉴定为Fonsecaea monophora。诊断为着色芽生菌病，予抗真菌联合治疗（伊曲康唑0.2 g，1次/d，特比萘芬0.25 g，1次/d），治疗4个月后患者疣状斑块增生明显好转，随访中。

关键词: Fonsecaea monophora, 着色芽生菌病, 伊曲康唑, 特比萘芬, 皮下真菌感染

Abstract: Here we report a case of chromoblastomycosis caused by Fonsecaea momophora. A 80-year-old man was admitted to the hospital with a more than eleven years’s history of plaque on the right hand. Direct microscopic examination and fungal culture, histopathologic examination, ribosomal internal transcribed spacer (ITS) sequence analysis were performed. The thick-walled, brown sclerotic bodies were observed by direct microscopic examination and histopathological examination. Fungal culture yielded black brown villiform colonies and rhinocladiella type and cladosporium type conidia were observed in the slide culture. The isolate was identified as Fonsecaea momophora according to the ITS sequencing. The patient was prescribled itraconazole(200 mg/d) combined with terbinafine (250 mg/d) for 4 months.The lesions improved greatly and the patient was now under followed-up.

Key words: Fonsecaea monophora, chromoblastomycosis, itraconazole, terbinafine, subcutaneous mycoses

中图分类号:

R756.6

牛牧, 廖万清, 吴伟伟, 郑文爱. Fonsecaea monophora所致海南渔民着色芽生菌病1例[J]. 中国真菌学杂志, 2021, 16(3): 184-187.

NIU Mu, LIAO Wanqing, WU Weiwei, ZHENG Wenai. A case of Chromoblastomycosis caused by Fonsecaea monophora in Hainan fisherman[J]. Chinese Journal of Mycology, 2021, 16(3): 184-187.

参考文献

[1] Queiroz-Telles F,Esterre P,Perez-Blanco M,et al.Chromoblastomycosis: an overview of clinical manifestations, diagnosis and treatment[J].Med Mycol,2009,47(1):3-15.
[2] Yap FB.Chromoblastomycosis[J].Int J Infect Dis,2010,14(6):543-544.
[3] Queiroz-Telles F, de Hoog S, Santos DW, et al. Chromoblastomycosis[J]. Clin Microbiol Rev.2017,30(1):233-276.
[4] Brito AC,Bittencourt MJS.Chromoblastomycosis:an etiological,epidemiolog-ical,clinical,diagnostic,and treatment update[J].An Bras Dermato,2018,93(4):495-506.
[5] Deng S, Tsui CK,Gerrits van den Ende AH, et al. Global spread of human chromoblastomycosis is driven by recombinant Cladophialophora carrionii and predominantly clonal Fonsecaea species[J].PLoS Negl Trop Dis,2015,9(10):e0004004.
[6] Queiroz-Telles F,Nucci M,Colombo AL,et al.Mycoses of implantation in Latin America: an overview of epidemiology, clinical manifestations, diagnosis and treatment[J].Med Mycol,2011,49(3):225-236.
[7] Agarwal R,Singh G,Ghosh A,et al.Chromoblastomycosis in India: Review of 169 cases[J].PLoS Negl Trop Dis,2017,11(8):e0005534.
[8] Queiroz-Telles F,de Hoog S,Santos DW,et al.Chromoblastomycosis[J].Clin Microbiol Rev,2017,30(1):233-276.
[9] 孙祺琳,余敏,陈骏,等.中国大陆地区52例皮肤着色芽生菌病回顾性分析[J],中国真菌学杂志,2020,15(2):101-105.
[10] De Hoog GS,Attili-Angelis D,Vicente VA,et al. Molecular ecology and pathogenic potential of Fonsecaea species[J].Med Mycol,2004,42(5):405-416.
[11] Xi L,Sun J,Lu C,et al. Molecular diversity of Fonsecaea(Chaetothyriales) causing chromoblastomycosis in southern China[J].Med Mycol,2009,47(1):27-33.
[12] 周欣,刘玉梅,高爱莉,等. Fonsecaea monophora所致皮肤着色芽生菌病3例病原学鉴定及临床分析[J].中国皮肤性病学杂志,2015,29(8):798-801.
[13] 李东明,李若瑜,王端礼,等.致病性外瓶霉的PCR-RELP分类[J].中华皮肤科杂志,2000,29(1):10-12.
[14] Queiróz AJR, Pereira Domingos F, Antônio JR. Chromoblastomycosis: clinical experience and review of literature[J]. Int J Dermatol, 2018, 57(11): 1351-1355.
[15] Bonifaz A,Paredes-Solís V,Saúl A.Treating chromoblastomycosis with systemic antifungals[J].Expert Opin Pharmacother,2004,5(2):247-254.
[16] Ameen M.Managing chromoblastomycosis[J].Trop Doct,2010,40(2):65-67.
[17] Ameen M.Chromoblastomycosis:clinical presentation and management[J]. Clin Exp Dermatol,2009,34(8):849-854.