口腔念珠菌病患者念珠菌分离株的菌种分布及流行趋势分析

中国真菌学杂志　 2021, Vol. 16 　Issue (3): 166-169,181.

口腔念珠菌病患者念珠菌分离株的菌种分布及流行趋势分析

宋扬, 贺静, 何淳

北京大学口腔医院, 北京 100081

收稿日期:2021-03-30 出版日期:2021-06-28 发布日期:2021-06-28
通讯作者: 何淳,E-mail:hechun008@sohu.com E-mail:hechun008@sohu.com
作者简介:宋扬,男(汉族),本科,检验技师.E-mail:DCZDjjx@126.com
基金资助:
北京大学口腔医院临床新技术新疗法项目（PKUSSNCT-15B15）

Distribution and epidemic trend of Candida isolates from patients with oral candidiasis

SONG Yang, HE Jing, HE Chun

Department of Clinical Laboratory, Peking University stomatological hospital, Beijing 100081, China

Received:2021-03-30 Online:2021-06-28 Published:2021-06-28

摘要/Abstract

摘要： 目的回顾性分析我院近5年口腔黏膜科念珠菌病患者的念珠菌分布及流行趋势。方法对2015年至2019年到北京大学口腔医院黏膜科就诊的27162例患者的唾液培养样本结果进行回顾性分析。将所有结果录入Excel表格后按照菌种、菌量、患者性别、患者年龄进行分组分析。结果在2015至2019年分离自口腔念珠菌病患者的所有念珠菌菌株中，白念珠菌所占的比例最高，热带念珠菌和其他念珠菌的阳性比例呈现逐年上升趋势。在白念珠菌、热带念珠菌、光滑念珠菌感染的样本中均以菌落数≥200 CFU/mL的菌株为主，而克柔念珠菌、其他念珠菌菌落数≥200 CFU/mL的菌株比例低于白念珠菌、热带念珠菌和光滑念珠菌，而菌落数≤30 CFU/mL的菌株比例明显高于白念珠菌、热带念珠菌和光滑念珠菌。统计分析结果显示，女性患者占比明显高于男性患者（P<0.05）。口腔念珠菌各年龄段的占比总体随年龄的增长呈现升高趋势，且在41~50岁年龄段及其后升高明显。结论虽然白念珠菌感染仍然是口腔念珠菌感染的主要病原菌，但热带念珠菌和其他念珠菌的阳性比例近年来呈现逐年上升趋势。口腔念珠菌病患者菌株分布和流行趋势分析对于临床用药策略有指导意义。

关键词: 口腔, 真菌感染, 念珠菌, 菌种分布

Abstract: Objective To analyze the distribution and epidemic trend of Candida isolates from oral candidiasis patients in our hospital in recent five years retrospectively. Methods A total of 27,162 saliva culture samples collected from the Mucosal Department of Peking University Hospital of Stomatology between 2015 and 2019 were retrospectively analyzed. All the results were entered into the Excel form and analyzed in groups according to different species distribution, funged quantities, sexes and ages. Results Among all the Candida strains isolated from oral candidiasis patients from 2015 to 2019, Candida albicans accounted for the highest proportion, while the positive proportion of Candida tropicalis and other Candida increased year by year. In the samples infected by C. albicans, C. tropical and C. glabrata, the number of colonies was mainly ≥200 CFU/mL. However, the number of colonies in samples infected with C. kruseii and other Candida species is mainly ≤30 CFU/mL or ≥200 CFU/mL. In all study populations, the positive rate of infection in female patients was significantly higher than that in male patients (P<0.05), and the positive rate of oral infection generally increased with age and increased significantly after the 41~50 age group. Conclusion Although Candida albicans was still the main pathogen of oral Candida infection, the positive rate of Candida tropicalis and other Candida had been increasing year by year in recent years. The analysis of the distribution and epidemic trend of oral candidiasis might be useful for clinical medication strategy.

Key words: oral cavity, fungal infection, Candida, species distribution

中图分类号:

R379.4

宋扬, 贺静, 何淳. 口腔念珠菌病患者念珠菌分离株的菌种分布及流行趋势分析[J]. 中国真菌学杂志, 2021, 16(3): 166-169,181.

SONG Yang, HE Jing, HE Chun. Distribution and epidemic trend of Candida isolates from patients with oral candidiasis[J]. Chinese Journal of Mycology, 2021, 16(3): 166-169,181.

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