播散性马尔尼菲篮状菌病1例

中国真菌学杂志　 2021, Vol. 16 　Issue (2): 128-130,140.

播散性马尔尼菲篮状菌病1例

吴荣群¹, 徐文英¹, 李丽丽¹, 陈杏春², 韦海明³, 谢治¹

1. 广西壮族自治区人民医院皮肤性病科, 南宁 530000;
2. 广西壮族自治区人民医院检验科, 南宁 530000;
3. 广西壮族自治区人民医院病理科, 南宁 530000

收稿日期:2020-06-05 发布日期:2021-04-25
通讯作者: 谢治,E-mail:xz19723@126.com E-mail:xz19723@126.com
作者简介:吴荣群,女(汉族),本科,住院医师.E-mail:877227627@qq.com

A case of disseminated Talaromyces marneffei

WU Rongqun¹, XU Wenying¹, LI Lili¹, CHEN Xingchun², WEI Haiming³, XIE Zhi¹

1. Guangxi Zhuang Autonomous Region People's Hospital, Department of Dermatology, Nanning 530000, China;
2. Guangxi Zhuang Autonomous Region People's Hospital, Department of Laboratory Medicine, Nanning 530000, China;
3. Guangxi Zhuang Autonomous Region People's Hospital, Department of Pathology, Nanning 530000, China

Received:2020-06-05 Published:2021-04-25

摘要/Abstract

摘要： 患者，男，32岁，反复淋巴结肿大、发热伴皮疹2年，广谱抗生素、抗结核治疗无效，肺部CT提示两肺内多发结节，血γ干扰素抗体阳性，皮肤活检组织、淋巴结组织、肺穿刺活检组织均培养出马尔尼菲篮状菌，予两性霉素B脂质体联合伏立康唑治疗效果佳。

关键词: 马尔尼菲篮状菌病, 非艾滋病患者, γ干扰素抗体

Abstract: A 32-year-old man was admitted because of recurrent episodes of lymphadenectasis, fever and skin rashes for two years. Broad-spectrum antibiotics and anti-tuberculosis therapy were ineffective. Lung CT showed multiple nodules in both lungs and the serum was positive for anti-IFN-γ. Disseminated Talaromyces marneffei was diagnosed by skin biopsy, lymph node biopsy, lung biopsy. Amphotericin B liposome combined with voriconazole had a good therapeutic effect.

Key words: Talaromyces marneffei, non-HIV patient, anti-IFN-γ autoantibody

中图分类号:

R519.8

吴荣群, 徐文英, 李丽丽, 陈杏春, 韦海明, 谢治. 播散性马尔尼菲篮状菌病1例[J]. 中国真菌学杂志, 2021, 16(2): 128-130,140.

WU Rongqun, XU Wenying, LI Lili, CHEN Xingchun, WEI Haiming, XIE Zhi. A case of disseminated Talaromyces marneffei[J]. Chinese Journal of Mycology, 2021, 16(2): 128-130,140.

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