阿萨希毛孢子菌致白血病患者血流感染1例

中国真菌学杂志　 2021, Vol. 16 　Issue (2): 125-127.

阿萨希毛孢子菌致白血病患者血流感染1例

叶丽¹, 高灵素¹, 丁美琪¹, 王璐²

1. 安徽省六安市人民医院血液内科, 六安 237005;
2. 安徽省六安市人民医院检验科细菌室, 六安 237005

收稿日期:2020-07-01 发布日期:2021-04-25
作者简介:叶丽,女(汉族),硕士,副主任医师.E-mail:yeli_la@163.com

Trichosporon asahii sepsis in a patient with acute myeloid leukemia and literature review

YE Li¹, GAO Lingsu¹, DING Meiqi¹, WANG Lu²

1. Department of Hematology, Lu'an People's Hospital, Lu'an 237005, China;
2. Department of Bacteria, Laboratory, Lu'an People's Hospital, Lu'an 237005, China

Received:2020-07-01 Published:2021-04-25

摘要/Abstract

摘要： 患者，男，41岁，急性白血病化疗后骨髓抑制期出现高热，广谱抗生素覆盖，患者体温好转后再次高热。第1次发热血培养缓症链球菌/葡萄球菌。第2次发热血培养阿萨希毛孢子菌。血清隐球菌抗原（免疫胶体金法）阳性，胸部CT提示肺部感染。加用国产伏立康唑后体温曾下降，再次上升，换用进口伏立康唑患者未再发热，持续口服伏立康唑，2个月后复查胸部CT肺部病灶好转。

关键词: 急性白血病, 阿萨希毛孢子菌, 血流感染

Abstract: A case of acute leukemia with high fever during myelosuppression stage after chemotherapywas treated by broad-spectrum antibiotics. But high fever arose again after the patient's body temperature being improved. The first febrile blood culture result showed Streptococcus mitis/Staphylococcus. Trichosporon asahii was found in the second febrile blood culture. Serum cryptococcal antigen test (immunocolloidal gold method) was positive, chest CT showed lung infection. After the addition of domestic voriconazole, the body temperature once dropped and rose again. The patient who switched to imported voriconazole did not have fever again, and continued to take voriconazole orally. After 2 months, the chest CT lung lesions improved.

Key words: acute leukemia, Trichosporum asahii, bloodstream infection

中图分类号:

R519.8

叶丽, 高灵素, 丁美琪, 王璐. 阿萨希毛孢子菌致白血病患者血流感染1例[J]. 中国真菌学杂志, 2021, 16(2): 125-127.

YE Li, GAO Lingsu, DING Meiqi, WANG Lu. Trichosporon asahii sepsis in a patient with acute myeloid leukemia and literature review[J]. Chinese Journal of Mycology, 2021, 16(2): 125-127.

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