特比萘芬在皮下及深部真菌感染中的临床应用

摘要/Abstract

摘要： 特比萘芬丙烯胺类抗真菌药物，对丝状真菌、双相真菌及酵母菌具有广谱抗真菌活性。除了在皮肤癣菌感染中用作一线治疗用药，特比萘芬在皮肤皮下及深部真菌感染中，也有较为广泛的临床应用，是一种安全有效的治疗药物。

Abstract: Terbinafine is an active allylamine antifungal agent with a mechanism of inhibiting squalene epoxidase in the fungal cell membrane. Its spectrum of in vitro fungicidal activity includes a broad range of dermatophyte, filamentous, dimorphic fungi, and some yeast species. Terbinafine had been widely used as the first-line treatment for superficial dermatophyte infection. In nearly two decades, terbinafine also had been proved to be highly effective and safe for a variety of subcutaneous and deep fungal infections, either in monotherapy or in combination therapy.

Key words: terbinafine, subcutaneous fungal infection, deep mycosis

中图分类号:

R978.5
R.519

朱红梅, 温海. 特比萘芬在皮下及深部真菌感染中的临床应用[J]. 中国真菌学杂志, 2020, 15(6): 374-377.

ZHU Hong-mei, WEN Hai. Clinical application of terbinafine in the treatment of subcutaneous and deep mycosis[J]. Chinese Journal of Mycology, 2020, 15(6): 374-377.

参考文献

[1] Guanziroli E, Pavia G, Guttadauro A, et al. Deep dermatophytosis caused by Trichophyton verrucosum in an immunosuppressed patient:successful outcome with terbinafine[J]. Mycopathologia, 2019, 184(4):543-545.
[2] Boral H, Durdu M, Ilkit M. Majocchi's granuloma:current perspectives[J]. Infect Drug Resist, 2018,11:751-760.
[3] Wang X, Yang Y, Li R, et al. Two cases of dermatophytic granuloma successfully treated with terbinafine[J]. Mycopathologia, 2018, 183(3):611-614.
[4] Mayser PA.Majocchi granuloma. Advantages of optical brightener staining in a case report[J]. Hautarzt, 2014, 65(8):721-724.
[5] André NF,Canato M, Zanatta DA, et al. Majocchi granuloma on a child's face[J]. Dermatol Online J, 2018, 24(12):13030/qt89k4t6wj.
[6] Zhou S, Yang Y, Liu K, et al. A case report of widespread Majocchi's granuloma in a patient with systemic lupus erythematosus[J]. Mycopathologia, 2017, 182(5-6):577-581.
[7] Chou WY, Hsu CJ.A case report of Majocchi's granuloma associated with combined therapy of topical steroids and adalimumab[J]. Medicine (Baltimore), 2016, 95(2):e2245.
[8] Nolting C, Vennewald I, Seebacher C. Tinea follicularis presenting as trichophytic Majocchi granuloma[J]. Mycoses,1997,40(Suppl 1):73-75.
[9] Brod C, Benedix F, Röcken M, et al. Trichophytic Majocchi granuloma mimicking Kaposi sarcoma[J]. J Dtsch Dermatol Ges, 2007, 5(7):591-593.
[10] Rallis E,Katoulis A, Rigopoulos D. Pubic Majocchi's granuloma unresponsive to itraconazole successfully treated with oral terbinafine[J]. Skin Appendage Disord, 2016,1(3):111-113.
[11] Bakardzhiev I, Chokoeva A, Tchernev G, et al. Tinea profunda of the genital area. Successful treatment of a rare skin disease[J]. Dermatol Ther, 2016,29(3):181-183.
[12] Labadie JG,Guggina LM. Vulvar Majocchi granuloma and kerion formation in an immunocompetent female[J]. Dermatol Online J, 2019, 25(9):13030/qt4qv91478.
[13] Rouzaud C, Chosidow O, Brocard A, et al. Severe dermatophytosis in solid organ transplant recipients:A French retrospective series and literature review[J]. Transpl Infect Dis, 2018, 20(1). doi:10.1111/tid.12799.
[14] Namba HD,Umemura H, Asagoe K. Eumycetoma caused by Trichophyton species successfully treated with terbinafine and surgery[J]. J Dermatol, 2017,44(5):e97-e98.
[15] Takenaka M, Yoshizaki A, Utani A, et al.A survey of 165 sporotrichosis cases examined in Nagasaki prefecture from 1951 to 2012[J]. Mycoses, 2014,57(5):294-398.
[16] 116-Mahajan VK.Sporotrichosis:an overview and therapeutic options[J]. Dermatol Res Pract, 2014, 2014:272376.
[17] Tanuma H, Asai T, Abe M, et al. Case report. Lymphatic vessel-type sporotrichosis:immunohistochemical evaluation and cytokine expression pattern[J]. Mycoses, 2001,44(7-8):316-320.
[18] Francesconi G, Valle AC, Passos S, et al.Terbinafine (250 mg/day):an effective and, safe treatment of cutaneous sporotrichosis[J]. J Eur Acad Dermatol Venereol, 2009, 23(11):1273-1276.
[19] Francesconi G, Francesconi do Valle AC, Passos SL, et al. Comparative study of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis[J]. Mycopathologia, 2011, 171(5):349-354.
[20] Chapman SW, Pappas P, Kauffmann C,et al.Comparative evaluation of the efficacy and safety of two doses of terbinafine (500 and 1000 mg day(-1)) in the treatment of cutaneous or lymphocutaneous sporotrichosis[J]. Mycoses, 2004, 47(1-2):62-68.
[21] Hull PR,Vismer HF. Treatment of cutaneous sporotrichosis with terbinafine[J]. Br J Dermatol, 1992, 126(Suppl 39):51-55.
[22] Coskun B, Saral Y, Akpolat N, et al.Sporotrichosis successfully treated with terbinafine and potassium iodide:case report and review of the literature[J]. Mycopathologia, 2004, 158(1):53-56.
[23] Guo K, Wang S, Wang Z,et al.Effective treatment using itraconazole combined with terbinafine in the treatment of nasal sporotrichosis:A case report[J]. Medicine (Baltimore). 2019, 98(37):e17155.
[24] Fan B, Wang JF,Zheng B, et al. Clinical features of 10 cases of eyelid sporotrichosis in Jilin Province (Northeast China)[J]. Can J Ophthalmol, 2016,51(4):297-301.
[25] Ryder NS.Activity of terbinafine against serious fungal pathogens[J]. Mycoses, 1999,42(Suppl 2):115-119.
[26] Hay RJ. Therapeutic potential of terbinafine in subcutaneous and systemic mycoses[J]. Br J Dermatol,1999,141(Suppl 56):36-40.
[27] Ryder NS,Leitner I. Synergistic interaction of terbinafine with triazoles or amphotericin B against Aspergillus species[J]. Med Mycol, 2001, 39(1):91-95.
[28] Glampedakis E, Coste AT, Aruanno M, et al. Efficacy of antifungal monotherapies and combinations against Aspergillus calidoustus[J]. Antimicrob Agents Chemother.2018, 62(12):e01137-18.
[29] Estrada R, Chávez-López G, Estrada-Chávez G, et al. Eumycetoma[J]. Clin Dermatol, 2012,30(4):389-96.
[30] Wang CH, Chen WT, Ting SW,et al.Subcutaneous fungal infection caused by a non-sporulating strain of Corynespora cassiicola successfully treated with terbinafine[J]. Mycopathologia. 2019,184(5):691-697.
[31] Inano S, Kimura M, Iida J,et al.Combination therapy of voriconazole and terbinafine for disseminated fusariosis:case report and literature review[J]. J Infect Chemother. 2013,19(6):1173-1180.
[32] Jenks JD, Seidel D,Cornely OA,et al.Voriconazole plus terbinafine combination antifungal therapy for invasive Lomentospora prolificans infections:analysis of 41 patients from the Fungi Scope© registry 2008-2019[J]. Clin Microbiol Infect, 202026(6):784.e1-e5.