特比萘芬耐药皮肤癣菌的研究进展

摘要/Abstract

摘要：

特比萘芬对皮肤癣菌具有强大的杀真菌活性，研发上市应用至今近30年，在皮肤癣菌相关感染中被大量用作一线治疗用药。但近年来，出现了少量皮肤癣菌特比萘芬耐药株的报道，研究发现绝大多数耐药菌株存在角鲨烯环氧化酶（squalene epoxidase，SQLE）基因的突变。皮肤癣菌的特比萘芬耐药现象多数为个案报告，但印度等地的局部病例增多并有向全球播散输出的倾向，应引起临床警惕和关注。

关键词: 特比萘芬耐药, 皮肤癣菌, 趾间毛癣菌, 印度, 角鲨烯环氧化酶, 点突变

中图分类号:

R379.2

朱红梅, 温海. 特比萘芬耐药皮肤癣菌的研究进展[J]. 中国真菌学杂志, 2020, 15(4): 253-256.

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特比萘芬耐药皮肤癣菌的研究进展

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