中国大陆地区52例皮肤着色芽生菌病回顾性分析

中国真菌学杂志　 2020, Vol. 15 　Issue (2): 101-105.

中国大陆地区52例皮肤着色芽生菌病回顾性分析

孙祺琳¹, 余敏², 陈骏¹, 刘洋¹, 廖万清³, 徐慧¹, 杨雅骊¹

1. 上海交通大学医学院附属第九人民医院皮肤科, 上海 200011;
2. 重庆北部宽仁医院麻醉科, 重庆 401121;
3. 上海长征医院皮肤病与真菌病研究所全军真菌病重点实验室上海市医学真菌分子生物学重点实验室海军军医大学附属长征医院皮肤科, 上海 200003

收稿日期:2019-11-13 出版日期:2020-04-28 发布日期:2020-04-28
通讯作者: 徐慧,E-mail:xusunan@hotmail.com;杨雅骊,E-mail:ky7812@126.com E-mail:xusunan@hotmail.com;ky7812@126.com
作者简介:孙祺琳,女(汉族),硕士,主治医师.E-mail:sarah_sql@163.com
基金资助:
国家自然科学基金青年项目（81501728）；国家卫生部国家重大科研项目（2018ZX10101003）；上海市卫生和计划生育委员会基金（2017ZZ01024-001）

Retrospective analysis of chromoblastomycosis in mainland China: a review of 52 cases

SUN Qi-lin¹, YU Min², CHEN Jun¹, LIU Yang¹, LIAO Wan-qing³, XU Hui¹, YANG Ya-li¹

1. Department of Dermatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China;
2. Department of Anesthesiology, Chungking General Hospital, Chongqing, 401121, China;
3. Department of dermatology, Changzheng Hospital, Institute of dermatology and medical mycology, Changzheng Hospital, Key laboratory of molecular medical mycology, PLA key laboratory of medical mycology, Shanghai key laboratory of Molecular Mycology, Shanghai 200003, China

Received:2019-11-13 Online:2020-04-28 Published:2020-04-28

摘要/Abstract

摘要：

目的总结与探讨中国大陆地区皮肤着色芽生菌病的流行病学及诊疗情况。方法检索分析重庆维普、中国知网、万方数据库及PubMed等数据库中1994年~2018年中国大陆地区确诊为皮肤着色芽生菌病的相关文献资料。结果共检索文献29篇，病例52例。患者平均发病年龄为53.9岁，男女比例为5.5∶1。本病好发于农民和工人，以四肢远端暴露部位较为常见，发病前多伴有外伤史；发病早期多以丘疹为主，随后多表现为斑块，结节和溃疡；真菌学检查菌株以裴氏着色芽生菌为主，治疗多以伊曲康唑和特比萘芬最常用，预后较好。结论皮肤着色真菌病是一种慢性难治的皮下肉芽肿性疾病，临床表现多样，晚期可致畸致残，甚至癌变，对该病的早期诊断和治疗非常重要。

关键词: 着色芽生菌, 真菌, 流行病学

Abstract:

Objective To summarize and explore the epidemiology, diagnosis and treatment of chromoblastomycosis in mainland China. Methods The relevant literatures about chromoblastomycosis in mainland China were collected from the electrical databases since 1994, such as Chongqing Weipu, China knowledge Network, Wanfang Database and PubMed database. Results A total of 29 literatures and 52 cases were searched. The average age of onset was 53.9 years old, and the ratio of male to female was 5.5:1; the disease was common in farmers and workers, with a history of trauma in the distal part of the extremities; most of the early onset is mainly papules, followed by plaques, nodules and ulcers; mycological examination strains is mainly Fonsecaea pedrosoi, and the most common treatments are itraconazole and terbinafine. The prognosis is good. Conclusions Chromomycosis is a chronic and refractory subcutaneous granulomatous disease with various clinical manifestations. It can cause teratogenic disability and even cancer in the late stage. Early diagnosis and treatment of the disease is very important.

Key words: chromoblastomycosis, fungus, epidemiology

中图分类号:

R519.2

孙祺琳, 余敏, 陈骏, 刘洋, 廖万清, 徐慧, 杨雅骊. 中国大陆地区52例皮肤着色芽生菌病回顾性分析[J]. 中国真菌学杂志, 2020, 15(2): 101-105.

SUN Qi-lin, YU Min, CHEN Jun, LIU Yang, LIAO Wan-qing, XU Hui, YANG Ya-li. Retrospective analysis of chromoblastomycosis in mainland China: a review of 52 cases[J]. Chinese Journal of Mycology, 2020, 15(2): 101-105.

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