NLRP3炎症小体在真菌感染中的作用机制研究进展

摘要/Abstract

摘要：

炎症小体（Inflammasome）是细胞内识别危险信号的多蛋白复合体，是固有免疫的重要组成部分，NOD样受体家族含热蛋白结构域蛋白3炎症小体（NLRP3）是目前研究最多的一种炎症小体。真菌感染中，NLRP3炎症小体通路募集半胱天冬蛋白酶的前体半胱氨酸天冬氨酸蛋白酶1（pro-caspase-1）自身剪切活化，活化后的半胱天冬蛋白酶（Caspase-1），通过对促炎因子IL-1β（interleukin-1β，IL-1β）和IL-18（interleukin-18，IL-18）的激活，引起宿主的炎症反应，在宿主免疫应答中发挥了重要作用。

关键词: NLRP3炎症小体, 固有免疫, 白念珠菌, 许兰毛癣菌, 烟曲霉

中图分类号:

R756

姬名硕, 王晓东, 帕丽达·阿布利孜. NLRP3炎症小体在真菌感染中的作用机制研究进展[J]. 中国真菌学杂志, 2019, 14(4): 253-256.

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