1935例深部曲霉临床分离株资料回顾性分析

中国真菌学杂志　 2019, Vol. 14 　Issue (4): 217-221.

1935例深部曲霉临床分离株资料回顾性分析

粟慧琳, 陈宗倩, 朱均昊, 李莉, 章强强, 徐金华, 朱敏

复旦大学附属华山医院皮肤科, 上海 200040

收稿日期:2019-06-17 出版日期:2019-08-28 发布日期:2019-08-28
通讯作者: 朱敏,E-mail:juneminmyco@126.com E-mail:juneminmyco@126.com
作者简介:粟慧琳,女(汉族),博士,住院医师.E-mail:911387967@qq.com;陈宗倩,女(汉族),本科,技师.E-mail:chenliang520g@qq.com
基金资助:
973计划项目（2013CB531600）

Retrospective analysis of 1935 clinical deep Aspergillus isolates

SU Hui-lin, CHEN Zong-qian, ZHU Jun-hao, LI Li, ZHANG Qiang-qiang, XU Jin-hua, ZHU Min

Department of Dermatology, Huashan hospital, Fudan University, Shanghai 200040

Received:2019-06-17 Online:2019-08-28 Published:2019-08-28

摘要/Abstract

摘要：

目的了解我院深部分离的曲霉菌种构成和临床分布特点，了解烟曲霉感染患者的基础疾病，指导临床烟曲霉深部感染的防治。方法收集2012年1月~2018年12月我院真菌室分离自临床深部标本的曲霉菌株以及其宿主的临床资料进行统计分析。结果 2012~2018年我院真菌室临床深部标本分离的曲霉菌株共计1935例，其中烟曲霉863例，黑曲霉159例，黄曲霉77例，未分类曲霉836例。烟曲霉主要分离自呼吸道标本，标本来源患者主要分布在传染科、呼吸科、老年高干科、ICU、抗生素科以及神经外科等科室。这些患者常见基础疾病为感染性疾病、肿瘤、非感染性的呼吸系统疾病、皮肤及风湿免疫系统疾病、内分泌系统疾病。结论我院深部标本分离的曲霉菌种主要为烟曲霉，主要引发肺部感染。我院分布于上述科室并合并上述基础疾病患者需警惕烟曲霉感染的发生。

关键词: 曲霉, 烟曲霉, 流行病学

Abstract:

Objective To investigate the constitutionand the clinical distribution of the Aspergillus species in our hospital. To study the underlying diseases of aspergillosis patients and guide the prevention and treatment of aspergillosis. Methods Clinical information of the Aspergillus species strains isolated in the mycology laboratoryof hospital from January 2012 to December 2018 was collected for statistical analysis. Results In total 1935 Aspergillus isolates from culture-positive specimen, there were 159 Aspergillus niger, 77 Aspergillus flavus, 863 Aspergillus fumigatus and 836 undefined Aspergillus species. Aspergillus fumigates strains were mainly isolated from respiratory specimens. Hospitalized patients with A. fumigatus specimens were mainly distributed in the departments of infectious diseases, respiratory diseases, geriatrics, intensive care unit (ICU), antibiotics, senior wards and neurosurgery. The main underlying diseases of patients with clinical diagnosis of A. fumigatus infection were infectious disease, other chronic lung disease, tumor, rheumatic disease, diabetes and so on. Conclusion A. fumigatus was the most common Aspergillus species in the clinic in our hospital and mainly caused lung infection. Patients in departments mentioned above with related underlying diseases should be alert to Aspergillus infection.

Key words: Aspergillus, Aspergillus fumigatus, epidemiology

中图分类号:

R519.8

粟慧琳, 陈宗倩, 朱均昊, 李莉, 章强强, 徐金华, 朱敏. 1935例深部曲霉临床分离株资料回顾性分析[J]. 中国真菌学杂志, 2019, 14(4): 217-221.

SU Hui-lin, CHEN Zong-qian, ZHU Jun-hao, LI Li, ZHANG Qiang-qiang, XU Jin-hua, ZHU Min. Retrospective analysis of 1935 clinical deep Aspergillus isolates[J]. Chinese Journal of Mycology, 2019, 14(4): 217-221.

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