长脉冲1064 nm激光联合酮康唑软膏封包病甲治疗甲真菌病的临床疗效观察

中国真菌学杂志　 2019, Vol. 14 　Issue (3): 154-158.

长脉冲1064 nm激光联合酮康唑软膏封包病甲治疗甲真菌病的临床疗效观察

曹艳云, 孙盈翡, 徐徉, 孔伟, 徐顺明

上海市浦东新区人民医院皮肤科, 上海 201299

收稿日期:2019-01-01 出版日期:2019-06-28 发布日期:2019-06-28
通讯作者: 徐顺明,13641930667@163.com E-mail:13641930667@163.com
作者简介:曹艳云,女(汉族),硕士,副主任医师.E-mail:cyy1980142003@sohu.com
基金资助:
浦东新区科技发展基金民生科研（医疗卫生）项目（PKJ 2016-Y07）；浦东新区卫生系统重点专科建设资助（PWZzk2017-28）

Clinical observation of long-pulsed 1064nm laser combined with ketoconazole ointment in the treatment of onychomycosis

CAO Yan-yun, SUN Ying-fei, XU Yang, KONG Wei, XU Shun-ming

Department of Dermatology, Pudong New Area People's Hospital, Shanghai 201299

Received:2019-01-01 Online:2019-06-28 Published:2019-06-28

摘要/Abstract

摘要：

目的观察长脉冲1064 nm激光联合酮康唑软膏封包病甲治疗甲真菌病的临床疗效。方法将73例甲真菌病门诊患者随机分为两组：联合组（37例，病甲75个）采用长脉冲1064 nm激光联合酮康唑软膏封包病甲治疗；对照组（36例，病甲87个）单纯使用激光治疗。每周1次，连续治疗8周，治疗6个月后随访评估。比较两种方法治疗甲真菌病的临床有效率，观察1064 nm激光联合酮康唑软膏封包病甲治疗甲真菌病患者的临床疗效。结果联合组治疗甲真菌病的总的临床有效率（74.67%）高于对照组（63.22%），3种临床类型在联合组的临床有效率均高于对照组，尤其近端甲下型（PSO）的临床有效率明显提高，但差异无统计学意义；当9 ≤ SCIO ≤ 15时，联合组治疗甲真菌病的临床有效率高于对照组，差异有统计学意义。结论对于9 ≤ SCIO ≤ 15的甲真菌病患者，长脉冲1064 nm激光联合酮康唑软膏封包病甲治疗甲真菌病的临床疗效显著高于单纯激光治疗。

关键词: 1064 nm激光, 甲真菌病, 甲真菌病临床评分指数(SCIO), 酮康唑软膏

Abstract:

Objective To observe the clinical efficacy of long-pulsed 1064nm laser combined with ketoconazole ointment in the treatment of onychomycosis. Methods Seventy-three outpatients with onychomycosis were randomly divided into two groups:the combined group (37 cases, 75 affected nails) was treated with 1064nm long-pulsed laser combined with ketoconazole ointment encapsulation of affected nails; the control group (36 cases, 87 affected nails) was treated with laser only. The patients were treated once a week for 8 weeks and followed up after 6 months. Results The total clinical effective rate (74.67%) of the combined group was higher than that of the control group (63.22%).The clinical effective rate of the three clinical types in the combined group was also higher than that of the control group, especially the proximal subungual type (PSO), but there was no significant difference in statistics. The clinical effective rate of onychomycosis with a score of 9 ≤ SCIO ≤ 15 in the combined group was higher than that of the control group. Conclusion The clinical efficacy of long-pulsed 1064nm laser combined with ketoconazole ointment in the treatment of onychomycosis patients with SCIO value of 9 ≤ SCIO ≤ 15 was significantly higher than that of laser only.

Key words: 1064nm laser, onychomycosis, scoring clinical index of onychomycosis (SCIO), ketoconazole ointment

中图分类号:

R756.4

曹艳云, 孙盈翡, 徐徉, 孔伟, 徐顺明. 长脉冲1064 nm激光联合酮康唑软膏封包病甲治疗甲真菌病的临床疗效观察[J]. 中国真菌学杂志, 2019, 14(3): 154-158.

CAO Yan-yun, SUN Ying-fei, XU Yang, KONG Wei, XU Shun-ming. Clinical observation of long-pulsed 1064nm laser combined with ketoconazole ointment in the treatment of onychomycosis[J]. Chinese Journal of Mycology, 2019, 14(3): 154-158.

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