1031例皮肤癣菌病及致病菌分析

中国真菌学杂志　 2019, Vol. 14 　Issue (2): 99-103.

1031例皮肤癣菌病及致病菌分析

姜伟伟¹, 扈东营¹, 侯晴¹, 杜明威², 李航³, 邓宇晨¹, 李帅⁴, 曹云⁴, 郑方伟⁵, 凌丽燕⁶, 于晓天⁷, 方文捷¹, 赵瑾¹, 潘炜华¹, 廖万清¹

1. 海军军医大学第二附属医院皮肤科, 上海 200003;
2. 哈尔滨医科大学(大庆校区)药学院, 大庆 163000;
3. 江西省胸科医院神经内科, 南昌 330000;
4. 延安市人民医院检验科, 延安 716000;
5. 杭州市余杭区中医院皮肤科, 杭州 311100;
6. 平湖市第二人民医院检验科, 平湖 314200;
7. 南开大学生命科学院, 天津 300000

收稿日期:2019-02-15 出版日期:2019-04-28 发布日期:2019-04-28
通讯作者: 潘炜华,E-mail:panweihua9@sina.com;赵瑾,E-mail:Zhaoj-an@163.com E-mail:panweihua9@sina.com;Zhaoj-an@163.com
作者简介:姜伟伟,男(汉族),硕士研究生在读.E-mail:914384879@qq.com
基金资助:
医学真菌生物样本库质量控制体系构建研究（16DZ0500401）；上海市真菌病与自身免疫性疾病临床医学中心（2017ZZ01024-001）；"海上丝绸之路"重要病原体的威胁感知和监测预警（2018ZX10101003）

Analysis of 1031 cases of dermatophytosis and the pathogenic dermatophytes

JIANG Wei-wei¹, HU Dong-ying¹, HOU Qing¹, DU Ming-wei², LI Hang³, DENG Yu-chen¹, LI Shuai⁴, CAO Yun⁴, ZHENG Fang-wei⁵, LING Li-yan⁶, YU Xiao-tian⁷, FANG Wen-jie¹, ZHAO Jin¹, PAN Wei-hua¹, LIAO Wan-qing¹

1. Department of Dermatology, Second Affiliated Hospital of Naval Military Medical University, Shanghai 200000;
2. School of Pharmacy, Harbin Medical University(Daqing Campus), Daqing 163000;
3. Department of Neurology, Jiangxi Thoracic Hospital, Nanchang 330000;
4. Laboratory Department of Yan'an People's Hospital, Yan'an 716000;
5. Hangzhou Yuhang District Hospital Dermatology Department, Hangzhou 311100;
6. Pinghu Second People's Hospital Laboratory Department, Pinghu 314200;
7. Academy of Life Sciences, Nankai University, Tianjin 300000

Received:2019-02-15 Online:2019-04-28 Published:2019-04-28

摘要/Abstract

摘要：

目的了解本院皮肤癣菌病患者的临床特点、易感因素、病原菌种的构成及分布等。方法对2013年1月~2017年12月收集在本院皮肤科门诊就诊、培养结果为阳性的1031例皮肤癣菌感染病例进行病种及致病菌种分析。使用SPSS 23.0软件对结果进行统计处理分析。结果 1031例皮肤癣菌病中，男性535例，女性496例，共分离出1033株皮肤癣菌，其中皮肤癣菌病的发病高峰为21~30岁、31~40岁年龄段。皮肤癣菌病患者分离出1种或1种以上其他真菌（非皮肤癣菌真菌）有71例（6.89%），分离出两种皮肤癣菌的有2例（0.19%），分离出最多的其他真菌是红酵母。最常见的皮肤癣菌病为甲癣（n=344，33.37%），其次为股癣（n=200，19.40%），体癣（n=162，15.71%），足癣（n=138，13.39%），手癣（n=108，10.48%），面癣（n=45，4.36%）和头癣（n=34，3.30%），其中股癣、甲癣等存在统计学意义上的性别差异。在菌种分布上，构成比前三依次为须癣毛癣菌（n=542，52.47%）、红色毛癣菌（n=397，38.43%）和犬小孢子菌（n=66，6.39%），其中红色毛癣菌和犬小孢子菌感染患者的性别差异有统计学意义。结论本院皮肤癣菌病以甲癣为主，主要致病菌为须癣毛癣菌，皮肤癣菌病及皮肤癣菌的分布特点和流行趋势与近年我国多数地区类似，但具备自身特点。

关键词: 皮肤癣菌病, 皮肤癣菌, 甲癣, 须癣毛癣菌, 红酵母

Abstract:

Objective To understand the clinical characteristics, susceptible factors, distribution of fungal pathogens of dermatophytosis in Shanghai. Methods All 1031 cases of dermatophytosis presented with typical clinical features and positive culture results were collected during January 2013 to December 2017 in our outpatient department for analysis. SPSS 23.0 was used in statistic analysis. Results Of 1031 cases of dermatophytosis, 535 were males and 496 were females, 1033 strains of dermatophytosis were isolated. The peak incidence of dermatophytosis was 21-30 years old and 31-40 years old. 71 cases (6.89%) had one or more other fungi isolated from patients with dermatophytosis, and 2 cases (0.19%) had two kinds of dermatophytes, in which the most isolated other fungi were Rhodotorula. The most common dermatophytosis was onychomycosis (n=344,33.37%), followed by tinea cruris (n=200,19.40%), tinea corporis (n=162,15.71%), tinea pedis (n=138,13.39%), tinea manus (n=108,10.48%), tinea facialis (n=45,4.36%) and tinea capitis (n=34, 3.30%), in which there were significant gender differences in tinea cruris and onychomycosis. In the distribution of strains, the top three were Trichophyton mentagrophytes (n=542, 52.47%), Trichophyton rubrum (n =397, 38.43%) and Microsporum canis (n=66, 6.39%), in which there were significant gender differences between Trichophyton rubrum and Microsporum canis. Conclusion The main type of dermatophytosis in our hospital was onychomycosis, and the main pathogen was Trichophyton mentagrophytes. The distribution and epidemic trend of dermatophytosis and dermatophytosis are similar to those in most areas of China in recent years, but it has its own characteristics.

Key words: Dermatophytosis, Dermatophyte, Tinea unguium, Trichophyton mentagrophytes, Rhodotorula spp

中图分类号:

R756

姜伟伟, 扈东营, 侯晴, 杜明威, 李航, 邓宇晨, 李帅, 曹云, 郑方伟, 凌丽燕, 于晓天, 方文捷, 赵瑾, 潘炜华, 廖万清. 1031例皮肤癣菌病及致病菌分析[J]. 中国真菌学杂志, 2019, 14(2): 99-103.

JIANG Wei-wei, HU Dong-ying, HOU Qing, DU Ming-wei, LI Hang, DENG Yu-chen, LI Shuai, CAO Yun, ZHENG Fang-wei, LING Li-yan, YU Xiao-tian, FANG Wen-jie, ZHAO Jin, PAN Wei-hua, LIAO Wan-qing. Analysis of 1031 cases of dermatophytosis and the pathogenic dermatophytes[J]. Chinese Journal of Mycology, 2019, 14(2): 99-103.

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