白念珠菌液泡的致病性作用

摘要/Abstract

摘要：

白念珠菌是常驻人体的条件致病性真菌，与机体处于共生状态，在正常人体不致病。当某些因素破坏这种平衡状态，如当机体免疫力下降和黏膜屏障功能受损时，白念珠菌由酵母相转为菌丝相，在局部大量生长繁殖，侵袭力增加，引起皮肤、黏膜甚至全身性的念珠菌病。随着真菌对经典药物耐药性的出现，新型抗真菌药物的研发就显得尤为重要。目前以白念珠菌液泡作为抗真菌药物靶点的研究正深入开展。该文就白念珠菌液泡功能在白念珠菌致病性中的研究进展作一综述。

关键词: 白念珠菌, 液泡, 毒性, V-ATPase

中图分类号:

R379.4

韩晓雨, 张景翔, 阎澜. 白念珠菌液泡的致病性作用[J]. 中国真菌学杂志, 2019, 14(1): 53-57.

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