关键词: 肺疾病, 曲霉菌, 慢性肺曲霉菌病

Abstract:

Objective To study the clinical features of chronic pulmonary aspergillosis(CPA),so as to provide evidence for early diagnosis and treatment. Methods A retrospective analysis was made upon clincial data, imaging features and laboratory tests of 55 patients with CPA. Results Of the 55 patients diagnosed with CPA, 34 patients were diagnosed with chronic cavitary pulmonary aspergillosis,15 patients with semi-invasive aspergillosis,4 patients with simple aspergilloma, and 2 patients with aspergillus nodule. There were 29 cases of chronic obstructive pulmonary disease(52.7%),6 cases of malignant tumor(10.9%),5 cases of pulmonary tuberculosis(9.1%),4 cases of asthma(7.3%),4 cases of bronchiectasis(7.3%) and 1 cases of interstitial lung disease(1.8%) in CPA. The most common symptoms in the CPA patients were cough(94.5%),sputum(81.8%),hemoptysis(54.5%),and fever(36.4%).The most common computerized tomography abnormalities were cavities(96.4%),nodule(63.6%),infiltration or consolidation(7.3%),and pleural thickening(5.5%). Conclusion CPA patients were usually associated with chronic obstructive pulmonary disease, malignant tumor, pulmonary tuberculosis, asthma, bronchiectasis and interstitial lung disease. Chronic cavitary pulmonary aspergillosis was the most common types of CPA. Actively searching for etiological and imaging evidences, including pneumocentesis or pulmonary resection if necessary, early antifungal treatment would improve prognosis of patients with CPA.

Key words: pulmonary disease, pulmonary aspergillosis, chronic pulmonary aspergillosis