血清PCT联合血浆1,3-β-D-葡聚糖检测对自身免疫性疾病合并侵袭性肺真菌病的诊断价值

中国真菌学杂志　 2018, Vol. 13 　Issue (6): 335-339.

血清PCT联合血浆1,3-β-D-葡聚糖检测对自身免疫性疾病合并侵袭性肺真菌病的诊断价值

陈荣¹, 刘敏², 张玮³

1. 鄂州市妇幼保健院, 鄂州 436000;
2. 宜昌市中心人民医院, 宜昌 443003;
3. 湖北省江汉油田总医院检验科, 潜江 433124

收稿日期:2018-03-09 出版日期:2018-12-28 发布日期:2018-12-28
作者简介:陈荣,女(汉族),硕士,主管技师.E-mail:chenrongqa@sina.com

Diagnosis value of combined detection of serum PCT and plasma 1,3-β-D-glucan in the autoimmune diseases with invasive pulmonary fungal infection

CHEN Rong¹, LIU Min², ZHANG Wei³

1. Ezhou maternal and Child Health Hospital, Ezhou 436000;
2. Yichang Central People's Hospital, Yichang 443003;
3. Clinical Laboratory, Jianghan Oil Field General Hospital of Hubei province, Qianjiang 433124

Received:2018-03-09 Online:2018-12-28 Published:2018-12-28

摘要/Abstract

摘要：

目的探讨血清降钙素（PCT）联合血浆1，3-β-D-葡聚糖检测对自身免疫性疾病（AID）合并侵袭性肺真菌病的诊断价值。方法选取医院收治的AID合并侵袭性肺真菌感染患者45例作为病例组，选取同收治的AID患者50例作为对照组，检测两组血清PCT和血浆1，3-β-D-葡聚糖水平，利用受试者工作特征曲线（ROC）评价血清PCT和血浆1，3-β-D-葡聚糖对自身免疫性疾病合并侵袭性肺真菌病的诊断价值。结果病例组血清PCT联合血浆1，3-β-D-葡聚糖水平均高于对照组，差异有统计学意义（P<0.05）；绘制ROC曲线，血清PCT的诊断截点为0.05 ng/mL，AUC为0.713，血浆1，3-β-D-葡聚糖诊断截点为20 ng/mL，AUC为0.851，两者联合诊断的AUC为0.936。两者联合诊断AID合并侵袭性肺真菌病的准确性、敏感性、特异性分别为92.63%、93.33%、92.0%，显著高于血清PCT检测的72.63%、72.63%、76.0%，差异有统计学意义（P<0.05），两者联合诊断的准确高于血浆1，3-β-D-葡聚糖诊断的81.05%（P<0.05），其余比较差异无统计学意义（P>0.05）。结论血清PCT联合血浆1，3-β-D-葡聚糖检测对AID合并侵袭性肺真菌病有较好的诊断效能。

关键词: 侵袭性肺真菌病, 降钙素, 1,3-β-D-葡聚糖, 诊断效能

Abstract:

Objective To investigate the diagnosis value of combined detection of serum calcitonin (PCT) and plasma 1,3-β-D-glucan in the autoimmune disease (AID) with invasive pulmonary fungal infection (IPFI). Methods Forty five patients with AID and IPFI were selected as the case group, and 50 patients with AID were selected as the control group at the same time. Levels of serum PCT and plasma 1,3-β-D-glucan in the two groups were detected. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum PCT and 1,3-β-D-glucan in AID with IPFI. Results Levels of serum PCT and plasma 1,3-β-D-glucan in the case group were higher than those in the control group (P<0.05). The ROC curves showed that the diagnostic cut-off point of serum PCT was 0.05 ng/mL, and the AUC was 0.713 while those of 1,3-β-D-glucan were 20 ng/mL and 0.851, respectively. The AUC of combined diagnosis was 0.936. The accuracy, sensitivity and specificity of combined diagnosis of AID with IPFI (92.63%, 93.33% and 92.0%) were significantly higher than those of serum PCT (72.63%, 72.63% and 76.0%) (P<0.05). The accuracy of combined diagnosis was higher than that of plasma 1,3-β-D-glucan (81.05%) (P<0.05), and there was no significant difference in the other (P>0.05). Conclusion Combined detection of serum PCT and plasma 1,3-β-D-glucan is of good diagnostic efficacy for AID with IPFI.

Key words: invasive pulmonary fungal infection, calcitonin, 1,3-β-D-glucan, diagnostic efficacy

中图分类号:

R519
R446.5

陈荣, 刘敏, 张玮. 血清PCT联合血浆1,3-β-D-葡聚糖检测对自身免疫性疾病合并侵袭性肺真菌病的诊断价值[J]. 中国真菌学杂志, 2018, 13(6): 335-339.

CHEN Rong, LIU Min, ZHANG Wei. Diagnosis value of combined detection of serum PCT and plasma 1,3-β-D-glucan in the autoimmune diseases with invasive pulmonary fungal infection[J]. Chinese Journal of Mycology, 2018, 13(6): 335-339.

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