白念珠菌黏附基因的研究进展

摘要/Abstract

摘要：

白念珠菌能引起免疫力低下患者的皮肤黏膜和全身系统性持续感染，对宿主组织的黏附是其侵入和感染的先决条件。对白念珠菌黏附相关基因的研究有助于揭示白念珠菌的致病机制。近年来，越来越多的研究者从黏附基因的结构、影响其表达的因素以及黏附机制等方面进行了研究。本文就黏附基因的相关研究进展进行综述，旨在为新型抗真菌药物和白念珠菌疫苗的研究提供参考。

关键词: 白念珠菌, 黏附基因, 毒力因素, 致病机制

Abstract:

Candida albicans causes superficial as well as life-threatening systemic infections in immunocompromised patients, and its adhesion to host tissues is a prerequisite for its invasion and infection. Studies on Candida albicans adhesion-related genes can help reveal the pathogenic mechanism of Candida albicans. Recently, more and more researchers have been devoted to clarify the structure of adhesion-related genes, factors affecting genes expression, and related adhesion mechanisms. In this article,progress in research in adhesion-related genes of C.albicans is reviewed,so as to provide a reference for the study of novel antifungal drug and vaccine against C.albicans infections.

Key words: Candida albicans, adhesion-related genes, virulence factor, pathogenic mechanism

中图分类号:

R379.4

赵晓霞, 冯文莉. 白念珠菌黏附基因的研究进展[J]. 中国真菌学杂志, 2018, 13(5): 309-313.

ZHAO Xiao-xia, FENG Wen-Li. Research progress of adhesion-related genes of Candida albicans[J]. Chinese Journal of Mycology, 2018, 13(5): 309-313.

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