磷酸泛酰巯基乙胺基转移酶在真菌和细菌的研究进展

中国真菌学杂志　 2018, Vol. 13 　Issue (5): 305-308.

磷酸泛酰巯基乙胺基转移酶在真菌和细菌的研究进展

孟玲宁^1,2, 刘锦燕², 赵悦^1,2, 吕婕³, 林伊静³, 项明洁^1,2

1. 上海交通大学医学院附属瑞金医院检验科, 上海 200025;
2. 上海交通大学医学院附属瑞金医院卢湾分院放免检验科, 上海 200020;
3. 上海交通大学医学院, 上海 200025

收稿日期:2018-02-26 出版日期:2018-10-28 发布日期:2018-10-28
通讯作者: 项明洁,E-mail:mjxiang123456@126.com E-mail:mjxiang123456@126.com
作者简介:孟玲宁,女(汉族),硕士研究生在读.E-mail:yimln16@163.com
基金资助:
上海市科委基金（15ZR1426900）；上海市医学重点专科（ZK2012A21）；上海市卫计委课题（201740069）；上海市黄浦区卫计委课题（HKM201702）

Phosphopantetheinyl transferases in fungi and bacteria research

MENG Ling-ning^1,2, LIU Jin-yan², ZHAO Yue^1,2, LV Jie³, LIN Yi-jing³, XIANG Ming-jie^1,2

1. Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China;
2. Radioimmunology and Clinical Laboratory, Luwan Branch, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200020, China;
3. Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

Received:2018-02-26 Online:2018-10-28 Published:2018-10-28

摘要/Abstract

摘要：

磷酸泛酰巯基乙胺基转移酶（phosphopantetheinyl transferases，PPTase）可催化脂肪酸合酶（fatty acid synthases，FAS）、聚酮合成酶（polyketide synthases，PKS）以及非核糖体肽合成酶（non-ribosomal peptide syntethases，NRPS）的酰基载体蛋白（acyl carrier protein，ACP）及肽酰载体蛋白（peptidyl carrier protein，PCP）等的翻译后修饰反应，将辅酶A（coenzyme A，CoA）上的磷酸泛酰巯基乙胺基转移到ACP及PCP的保守丝氨酸残基上，从而激发ACP及PCP的活性，由此脂肪酸、聚酮、非核糖体肽得以合成。在大部分真菌及细菌中都存在着PPTase，且其在生物代谢中起到重要的作用。现对其研究进展进行阐述。

关键词: 磷酸泛酰巯基乙胺基转移酶, 真菌, 细菌

Abstract:

Phosphopantetheinyl transferases (PPTases) catalyze the post-translational modification reactions of acyl carrier protein (ACP) and peptidyl carrier protein (PCP), carrier proteins of fatty acid synthase (FAS), polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS). Phosphopantetheinyl groups on coenzyme A (CoA), are transferred to conserved serine residues of ACP and PCP to stimulate their activity, therefore fatty acids, polyketides, non-ribosomal peptides are synthesized. PPTase exists in most fungi and bacteria, and it plays an important role in biological metabolism. Now the research progress is elaborated.

Key words: Phosphopantetheinyl transferases, fungi, bacteria

中图分类号:

R379
R378

孟玲宁, 刘锦燕, 赵悦, 吕婕, 林伊静, 项明洁. 磷酸泛酰巯基乙胺基转移酶在真菌和细菌的研究进展[J]. 中国真菌学杂志, 2018, 13(5): 305-308.

MENG Ling-ning, LIU Jin-yan, ZHAO Yue, LV Jie, LIN Yi-jing, XIANG Ming-jie. Phosphopantetheinyl transferases in fungi and bacteria research[J]. Chinese Journal of Mycology, 2018, 13(5): 305-308.

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