血单核细胞在真菌感染免疫的研究进展

中国真菌学杂志　 2018, Vol. 13 　Issue (4): 244-246.

血单核细胞在真菌感染免疫的研究进展

董嘉琤¹, 梁官钊¹, 刘维达^1,2

1. 中国医学科学院北京协和医学院皮肤病研究所, 南京 210042;
2. 江苏省皮肤病与性病重点分子生物学实验室, 南京 210042

收稿日期:2017-12-13 出版日期:2018-08-28 发布日期:2018-08-28
通讯作者: 刘维达,E-mail:liumyco@hotmail.com E-mail:liumyco@hotmail.com
作者简介:董嘉琤,女(汉族),硕士研究生在读.E-mail:dongjc2016@163.com
基金资助:
中国医学科学院医学与健康科技创新工程（2016-I2M-3-021）

Research on functions of mononuclear cells in fungal infection

DONG Jia-cheng¹, LIANG Guan-zhao¹, LIU Wei-da^1,2

1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042;
2. Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042

Received:2017-12-13 Online:2018-08-28 Published:2018-08-28

摘要/Abstract

摘要：

单核细胞在微生物感染病灶处活化并参与炎症反应，但单核细胞具体的抗真菌作用仍然不太清楚。单核细胞具有异质性，存在多个亚群，其在感染免疫中的角色各有不同。本文旨在探讨单核细胞分类及不同表型单核细胞在念珠菌、隐球菌、烟曲霉等真菌感染中的作用，为了解抗真菌免疫机制、监控和治疗真菌病提供新的思路。

关键词: 单核细胞, 异质性, 真菌感染

Abstract:

Monocytes participate in the inflammatory response and activate at the site of microbial infection. However, the specific antifungal effect of monocytes is still unclear. Monocytes are heterogeneous and present in multiple subsets that play different roles in immune system. This article aims to investigate the functions of different phenotypic mononuclear cells in fungal infections (such as Candida, Cryptococcus and Aspergillus fumigatus) and provides new idea for understanding the mechanism of antifungal immunity, and monitoring fungal diseases.

Key words: monocytes, heterogeneity, fungal infection

中图分类号:

R519

董嘉琤, 梁官钊, 刘维达. 血单核细胞在真菌感染免疫的研究进展[J]. 中国真菌学杂志, 2018, 13(4): 244-246.

DONG Jia-cheng, LIANG Guan-zhao, LIU Wei-da. Research on functions of mononuclear cells in fungal infection[J]. Chinese Journal of Mycology, 2018, 13(4): 244-246.

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