欢迎访问《中国真菌学杂志》杂志官方网站,今天是 分享到:

中国真菌学杂志 2018, Vol. 13  Issue (1): 1-3.

论著    下一篇

阿萨希毛孢子菌通过分泌铁载体在低铁限制性条件下生长

孙伟, 邓娟, 苏建荣   

  1. 首都医科大学附属北京友谊医院临检中心, 北京 100050
  • 收稿日期:2017-04-17 出版日期:2018-02-28 发布日期:2018-02-28
  • 通讯作者: 苏建荣,E-mail:sujr2012@163.com E-mail:sujr2012@163.com
  • 作者简介:孙伟,女(汉族),博士,主管技师.E-mail:sunwei010512@163.com
  • 基金资助:

    北京市优秀人才资助基金(2014000021469G267),首都医科大学基础临床合作基金(15JL27)

Trichosporon asahii could growunder iron-restricted condition through siderophore secretion

SUN Wei, DENG Juan, SU Jian-rong   

  1. Clinical Laboratory Centre of Beijing Friendship Hospital, Capital Medical University, Beijing 100050
  • Received:2017-04-17 Online:2018-02-28 Published:2018-02-28

摘要:

目的 探讨阿萨希毛孢子菌在低铁限制性条件下生长的机制,为后续联合常用抗真菌药物治疗播散性毛孢子菌病提供实验室依据。方法 200 μmol/L的去铁胺加入酵母浸出粉胨葡萄糖培养基(Yeast Extract Peptone Dextrose Medium,YPD)培养基中制备低铁限制性培养基,检测阿萨希毛孢子菌临床分离株在该培养基中的生长曲线,并检测低铁条件下,阿萨希毛孢子菌产生铁载体的情况。结果 阿萨希毛孢子菌的生长曲线不受低铁限制性条件的影响,且其在低铁环境下可以产生铁载体。结论 阿萨希毛孢子菌通过产生铁载体在低铁限制性条件下正常生长。

关键词: 阿萨希毛孢子菌, 铁载体, 铁离子

Abstract:

Objective To investigate the mechanism of the growth of Trichosporon asahii under iron-restricted condition,and provide laboratory evidence for the combined therapy with antifungals against disseminated trichosporonosis.Methods 200 μmol/L BPS was added to the YPD medium to prepare iron-restricted condition,then the growth curve of Trichosporon asahii in this medium was detected. Results The Trichosporon asahii grew normally under the iron-restricted condition,and siderophore was detected from the culture medium supernatants simultaneously. Conclusions Trichosporon asahii grew normally under the iron-restricted condition through siderophore secretion.

Key words: Trichosporon asahii, siderophore, iron

中图分类号: