Th17细胞在侵袭性烟曲霉病中双向调节作用的研究进展

中国真菌学杂志　 2017, Vol. 12 　Issue (5): 312-317.

Th17细胞在侵袭性烟曲霉病中双向调节作用的研究进展

耿婉如^1,2, 贺航咏¹, 童朝晖¹

1. 首都医科大学附属北京朝阳医院呼吸与危重症科, 北京 100032;
2. 内蒙古民族大学附属医院呼吸内科, 通辽 028000

收稿日期:2017-04-13 出版日期:2017-10-28 发布日期:2017-10-28
通讯作者: 童朝晖,E-mail:tongzhh@hotmail.com;贺航咏,E-mail:yonghang2004@sina.com E-mail:tongzhh@hotmail.com;yonghang2004@sina.com
作者简介:耿婉如,女(蒙古族),博士研究生在读.E-mail:geng-wanru@163.com
基金资助:
国家自然科学基金（81400003）

Received:2017-04-13 Online:2017-10-28 Published:2017-10-28

摘要/Abstract

摘要：

辅助性T细胞17（Th17）在机体侵袭性肺烟曲霉病中有防御和破坏性作用，一方面经常可以观察到曲霉菌感染后Th17细胞数量的增加，IL-17水平升高、或者Th17细胞促稳定因子IL-23的升高，其机制可能为分泌特异的细胞因子、介导自身免疫反应或者趋化效应性T细胞等几个方面；另一方面体内Th17细胞免疫反应可导致免疫损伤，其机制中主要包含直接作用和间接作用两种，直接作用表现为IL-17在体内外均可以促进烟曲霉生长，间接作用表现为IL-17可通过上调促炎介质、抑制Th1免疫反应或促进Th2免疫反应等机制促进炎症发生发展。Th17细胞对侵袭性肺烟曲霉病的这种双向调节作用主要与烟曲霉与感染环境如宿主免疫状态、感染时间、真菌细胞壁的特异成分的相互作用等有关。

关键词: Th17细胞, 侵袭性肺烟曲霉病, 免疫应答, 综述

中图分类号:

R519.8

耿婉如, 贺航咏, 童朝晖. Th17细胞在侵袭性烟曲霉病中双向调节作用的研究进展[J]. 中国真菌学杂志, 2017, 12(5): 312-317.

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