[1] Finkel T.Signal transduction by mitochondrial oxidants[J].J Biol Chem,2011,287(7):4434-4440.
[2] 纪元,龙建纲,刘健康.自噬发生中的ROS调节机制[J].中国生物化学与分子生物学报,2014,30(4):321-327.
[3] Hale AN,Ledbetter DJ,Gawriluk T R,et al.Autophagy:regulation and role in development[J].Autophagy,2013,9(7):951-972.
[4] Codogno P,Meijer AJ.Autophagy and signaling:their role in cell survival and cell death[J].Cell Death Differ,2005,12(Suppl 2):1509-1518.
[5] Pfaller MA,Diekema DJ.Epidemiology of invasive candidiasis:a persistent public health problem[J].Clin Microbiol Rev,2007,20(1):133-163.
[6] Palmer G E.Autophagy in the invading pathogen[J].Autophagy,2007,3(3):251-253.
[7] Bartoszewska M,Kiel JA.The role of macroautophagy in development of filamentous fungi[J].Antioxid Redox Signal,2011,14(11):2271-2287.
[8] Yu Q,Jia C,Dong Y,et al.Candida albicans autophagy,no longer a bystander:its role in tolerance to ER stress-related antifungal drugs[J].Fungal Genet Biol,2015,81:238-249.doi:10.1016/j.fgb.2015.02.008.
[9] Dong Y,Yu Q,Chen Y,et al.The Ccz1 mediates the autophagic clearance of damaged mitochondria in response to oxidative stress in Candida albicans[J].Int J Biochem Cell Biol,2015,69:41-51.doi:10.1016/j.biocel.2015.10.002.
[10] Wang CW,Klionsky DJ.The molecular mechanism of autophagy.[J].Molecular Medicine,2003,9(3-4):65-76.
[11] Palmer GE.Autophagy in Candida albicans[J].Methods Enzymol,2008,451(8):311-322.
[12] Abeliovich H,Klionsky DJ.Autophagy in yeast:mechanistic insights and physiological function[J].Microbiol Mol Biol Rev,2001,65(3):463.
[13] Baba M,Osumi M,Scott SV,et al.Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome[J].J Cell Biol,1997,139(7):1687-1695.
[14] Scott SV,Baba M,Ohsumi Y,et al.Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism[J].J Cell Biol,1997,138(1):37-44.
[15] Tuttle DL,Dunn WJ.Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris[J].J Cell Sci,1995,108(Pt1):25-35.
[16] Baba M,Takeshige K,Baba N,et al.Ultrastructural analysis of the autophagic process in yeast:detection of autophagosomes and their characterization[J].J Cell Biol,1994,124(6):903-913.
[17] Darsow T,Rieder SE,Emr SD.A multispecificity syntaxin homologue,Vam3p,essential for autophagic and biosynthetic protein transport to the vacuole[J].J Cell Biol,1997,138(3):517-529.
[18] Sato TK,Darsow T,Emr SD.Vam7p,a SNAP-25-like molecule,and Vam3p,a syntaxin homolog,function together in yeast vacuolar protein trafficking[J].Mol Cell Biol,1998,18(9):5308-5319.
[19] Noda T,Kim J,Huang WP,et al.Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways[J].J Cell Biol,2000,148(3):465-480.
[20] Lang T,Schaeffeler E,Bernreuther D,et al.Aut2p and Aut7p,two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole[J].EMBO J,1998,17(13):3597-3607.
[21] Matsuura A,Tsukada M,Wada Y,et al.Apg1p,a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae[J].Gene,1997,192(2):245-250.
[22] Rane HS,Bernardo SM,Hayek SR,et al.The contribution of Candida albicans vacuolar ATPase subunit V(1)B,encoded by VMA2,to stress response,autophagy,and virulence is independent of environmental pH[J].Eukaryot Cell,2014,13(9):1207-1221.
[23] Brown EJ,Albers MW,Shin TB,et al.A mammalian protein targeted by G1-arresting rapamycin-receptor complex[J].Nature,1994,369(6483):756-758.
[24] Kunz J,Henriquez R,Schneider U,et al.Target of rapamycin in yeast,TOR2,is an essential phosphatidylinositol kinase homolog required for G1 progression[J].Cell,1993,73(3):585-596.
[25] Uritani M,Hidaka H,Hotta Y,et al.Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase[J].Genes Cells,2006,11(12):1367-1379.
[26] Kamada Y,Sekito T,Ohsumi Y.Autophagy in yeast:a TOR-mediated response to nutrient starvation[J].Curr Top Microbiol Immunol,2004,279:73-84.
[27] Chang HJ,Ro SH,Jing C,et al.mTOR regulation of autophagy[J].Febs Letters,2010,584(7):1287-1295.
[28] Biswas K,Morschhauser J.The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans[J].Mol Microbiol,2005,56(3):649-669.
[29] Tsao CC,Chen YT,Lan CY.A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans[J].Fungal Genet Biol,2009,46(2):126-136.
[30] Cruz MC,Goldstein AL,Blankenship J,et al.Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR[J].Antimicrob Agents Chemother,2001,45(11):3162-3170.
[31] Ferrara A,Cafferkey R,Livi GP.Cloning and sequence analysis of a rapamycin-binding protein-encoding gene (RBP1) from Candida albicans[J].Gene,1992,113(1):125-127.
[32] Sabatini D M,Erdjument-Bromage H,Lui M,et al.RAFT1:a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs[J].Cell,1994,78(1):35-43.
[33] Cardenas ME,Cutler NS,Lorenz MC,et al.The TOR signaling cascade regulates gene expression in response to nutrients[J].Genes Dev,1999,13(24):3271-3279.
[34] Barbet NC,Schneider U,Helliwell SB,et al.TOR controls translation initiation and early G1 progression in yeast[J].Mol Biol Cell,1996,7(1):25-42.
[35] Feng J,Zhao Y,Duan Y,et al.Genetic interactions between protein phosphatases CaPtc2p and CaPph3p in response to genotoxins and rapamycin in Candida albicans[J].FEMS Yeast Res,2013,13(1):85-96.
[36] Zelante T,Iannitti R G,De Luca A,et al.Sensing of mammalian IL-17A regulates fungal adaptation and virulence[J].Nat Commun,2012,3:683.
[37] Rao A,Zhang Y,Muend S,et al.Mechanism of antifungal activity of terpenoid phenols resembles calcium stress and inhibition of the TOR pathway[J].Antimicrob Agents Chemother,2010,54(12):5062-5069. |