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中国真菌学杂志 2017, Vol. 12  Issue (2): 124-127.

综述 上一篇    

白念珠菌与生物膜相关的耐药机制

孟玲宁1,2, 刘锦燕2, 李文静1,2, 赵悦1,2, 项明洁1,2   

  1. 1. 上海交通大学医学院附属瑞金医院检验科, 上海 200025;
    2. 上海交通大学医学院附属瑞金医院卢湾分院放免检验科, 上海 200020
  • 收稿日期:2016-11-15 出版日期:2017-04-28 发布日期:2017-04-28
  • 通讯作者: 项明洁,E-mail:mjxiang123456@126.com E-mail:mjxiang123456@126.com
  • 作者简介:孟玲宁,女(汉族),硕士研究生在读.E-mail:yimln16@163.com
  • 基金资助:

    上海市科委基金(15ZR1426900);上海市医学重点专科(ZK2012A21);上海市黄浦区优秀青年人才(RCPY1407)

The resistance mechanisms of the biofilm related Candida albicans

MENG Ling-ning1,2, LIU Jin-yan2, LI Wen-jing1,2, ZHAO Yue1,2, XIANG Ming-jie1,2   

  1. 1. Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China;
    2. Radioimmunology and Clinical Laboratory, Luwan Branch, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200020, China
  • Received:2016-11-15 Online:2017-04-28 Published:2017-04-28

摘要:

白念珠菌在医疗植入材料上形成生物膜,导致高死亡率感染。成熟的生物膜具有强耐药性,使得生物膜相关感染难以治愈。文章主要从白念珠菌生物膜外排泵基因、细胞外基质以及压力应答等3个方面探讨白念珠菌生物膜的耐药机制,综述该研究方向的最新进展,为白念珠菌的临床防治策略制定提供参考。

关键词: 白念珠菌, 生物膜, 耐药机制, 细胞外基质

Abstract:

Candida albicans can form biofilms on medical implant materials, leading to high mortality infection.Mature biofilm related C.albicans infections are difficult to cure because of multi-drug resistance.This review discusses the resistance mechanisms of biofilm related C.albicans from efflux pump genes and matrix and stress response, summarizing the research advance of the mechanism and providing reference for clinical prevention strategies.

Key words: Candida albicans, biofilm, resistance mechanism, matrix

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