[1] Perfect JR,Hachem R,Wingard JR.Update on epidemiology of and preventive strategies for invasive fungal infections in cancer patients[J].Clin Infect Dis,2014,59(Suppl 5):S352-S355.
[2] Kullberg BJ,Arendrup MC.Invasive candidiasis[J].N Engl J Med,2015,373(15):1445-1456.
[3] Noble SM,Gianetti BA,Witchley JN.Candida albicans cell-type switching and functional plasticity in the mammalian host[J].Nat Rev Microbiol,2016,15(2):96-108.
[4] Lu Y,Su C,Liu H.Candida albicans hyphal initiation and elongation[J].Trends Microbiol,2014,22(12):707-714.
[5] Hogan DA,Sundstrom P.The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans[J].Future Microbiol,2009,4(10):1263-1270.
[6] Bourne HR,Sanders DA,McCormick F.The GTPase superfamily:a conserved switch for diverse cell functions[J].Nature,1990,348(6297):125-132.
[7] David R.Fungal biology:Ras1 as a switch for Candida albicans[J].Nat Rev Micro,2013,11(7):431-431.
[8] Fang HM,Wang Y.RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development[J].Mol Microbiol,2006,61(2):484-496.
[9] Zhu Y,Fang HM,Wang YM,et al.Ras1 and Ras2 play antagonistic roles in regulating cellular cAMP level,stationary-phase entry and stress response in Candida albicans[J].Mol Microbiol,2009,74(4):862-875.
[10] Bojsen R,Regenberg B,Gresham D,et al.A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations[J].Sci Rep,2016,6:21874.
[11] Maidan MM,De Rop L,Serneels J,et al.The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans[J].Mol Biol Cell,2005,16(4):1971-1986.
[12] Grahl N,Demers EG,Lindsay AK,et al.Mitochondrial activity and Cyr1 are key regulators of Ras1 activation of C.albicans virulence pathways[J].PLoS Pathog,2015,11(8):e1005133.
[13] Shapiro RS,Uppuluri P,Zaas AK,et al.Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling[J].Curr Biol,2009,19(8):621-629.
[14] Seneviratne CJ,Zeng G,Truong T,et al.New "haploid biofilm model" unravels IRA2 as a novel regulator of Candida albicans biofilm formation[J].Sci Rep,2015,5:12433.
[15] Hollomon JM,Grahl N,Willger SD,et al.Global role of cyclic AMP signaling in pH-dependent responses in Candida albicans[J].mSphere,2016,1(6):e00283-00216.
[16] Bahn YS,Sundstrom P.CAP1,an adenylate cyclase-associated protein gene,regulates bud-hypha transitions,filamentous growth,and cyclic AMP levels and is required for virulence of Candida albicans[J].J Bacteriol,2001,183(10):3211-3223.
[17] Zou H,Fang HM,Zhu Y,et al.Candida albicans Cyr1,Cap1 and G-actin form a sensor/effector apparatus for activating cAMP synthesis in hyphal growth[J].Mol Microbiol,2010,75(3):579-591.
[18] Neer EJ.Heterotrimeric G proteins:organizers of transmembrane signals[J].Cell,1995,80(2):249-257.
[19] Sabina J,Brown V.Glucose sensing network in Candida albicans:a sweet spot for fungal morphogenesis[J].Eukaryot Cell,2009,8(9):1314-1320.
[20] Miwa T,Takagi Y,Shinozaki M,et al.Gpr1,a putative G-protein-coupled receptor,regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans[J].Eukaryot Cell,2004,3(4):919-931.
[21] Ballou ER,Avelar GM,Childers DS,et al.Lactate signalling regulates fungal beta-glucan masking and immune evasion[J].Nat Microbiol,2016,2:16238.
[22] Jung WH,Warn P,Ragni E,et al.Deletion of PDE2,the gene encoding the high-affinity cAMP phosphodiesterase,results in changes of the cell wall and membrane in Candida albicans[J].Yeast,2005,22(4):285-294.
[23] Bahn YS,Staab J,Sundstrom P.Increased high-affinity phosphodiesterase PDE2 gene expression in germ tubes counteracts CAP1-dependent synthesis of cyclic AMP,limits hypha production and promotes virulence of Candida albicans[J].Mol Microbiol,2003,50(2):391-409.
[24] Wilson D,Tutulan-Cunita A,Jung W,et al.Deletion of the high-affinity cAMP phosphodiesterase encoded by PDE2 affects stress responses and virulence in Candida albicans[J].Mol Microbiol,2007,65(4):841-856.
[25] Giacometti R,Kronberg F,Biondi RM,et al.Cross regulation between Candida albicans catalytic and regulatory subunits of protein kinase A[J].Fungal Genet Biol,2012,49(1):74-85.
[26] Cloutier M,Castilla R,Bolduc N,et al.The two isoforms of the cAMP-dependent protein kinase catalytic subunit are involved in the control of dimorphism in the human fungal pathogen Candida albicans[J].Fungal Genet Biol,2003,38(1):133-141.
[27] Fanning S,Xu W,Beaurepaire C,et al.Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1[J].Mol Microbiol,2012,86(2):284-302.
[28] Giacometti R,Kronberg F,Biondi RM,et al.Candida albicans Tpk1p and Tpk2p isoforms differentially regulate pseudohyphal development,biofilm structure,cell aggregation and adhesins expression[J].Yeast,2011,28(4):293-308.
[29] Bockmuhl DP,Krishnamurthy S,Gerads M,et al.Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans[J].Mol Microbiol,2001,42(5):1243-1257.
[30] Cassola A,Parrot M,Silberstein S,et al.Candida albicans lacking the gene encoding the regulatory subunit of protein kinase A displays a defect in hyphal formation and an altered localization of the catalytic subunit[J].Eukaryot Cell,2004,3(1):190-199.
[31] Staniszewska M,Bondaryk M,Swoboda-Kopec E,et al.Candida albicans morphologies revealed by scanning electron microscopy analysis[J].Braz J Microbiol,2013,44(3):813-821.
[32] Caplice N,Moran GP.Candida albicans exhibits enhanced alkaline and temperature induction of Efg1-regulated transcripts relative to Candida dubliniensis[J].Genom Data,2015,6(30 Suppl 1):130-135.
[33] Connolly LA,Riccombeni A,Grozer Z,et al.The APSES transcription factor Efg1 is a global regulator that controls morphogenesis and biofilm formation in Candida parapsilosis[J].Mol Microbiol,2013,90(1):36-53.
[34] Zhao Y,Su H,Zhou J,et al.The APSES family proteins in fungi:Characterizations,evolution and functions[J].Fungal Genet Biol,2015,81:271-280.
[35] Noffz CS,Liedschulte V,Lengeler K,et al.Functional mapping of the Candida albicans Efg1 regulator[J].Eukaryot Cell,2008,7(5):881-893.
[36] Wartenberg A,Linde J,Martin R,et al.Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant[J].PLoS Genet,2014,10(12):e1004824.
[37] Giusani AD,Vinces M,Kumamoto CA.Invasive filamentous growth of Candida albicans is promoted by Czf1p-dependent relief of Efg1p-mediated repression[J].Genetics,2002,160(4):1749-1753.
[38] Lu Y,Su C,Mao X,et al.Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans[J].Mol Biol Cell,2008,19(10):4260-4272.
[39] James KM,MacDonald KW,Chanyi RM,et al.Inhibition of Candida albicans biofilm formation and modulation of gene expression by probiotic cells and supernatant[J].J Med Microbiol,2016,65(4):328-336.
[40] Phan QT,Eng DK,Mostowy S,et al.Role of endothelial cell septin 7 in the endocytosis of Candida albicans[J].MBio,2013,4(6):e00542-00513.
[41] Doedt T,Krishnamurthy S,Bockmuhl DP,et al.APSES proteins regulate morphogenesis and metabolism in Candida albicans[J].Mol Biol Cell,2004,15(7):3167-3180.
[42] Moazeni M,Khoramizadeh MR,Teimoori-Toolabi L,et al.The effect of EFG1 gene silencing on down-regulation of SAP5 gene,by use of RNAi technology[J].Acta Med Iran,2014,52(1):9-14.
[43] Liu JY,Li WJ,Shi C,et al.Mutations in the Flo8 transcription factor contribute to virulence and phenotypic traits in Candida albicans strains[J].Microbiol Res,2015,178:1-8.
[44] Ryan O,Shapiro RS,Kurat CF,et al.Global gene deletion analysis exploring yeast filamentous growth[J].Science,2012,337(6100):1353-1356.
[45] Fox EP,Bui CK,Nett JE,et al.An expanded regulatory network temporally controls Candida albicans biofilm formation[J].Mol Microbiol,2015,96(6):1226-1239.
[46] Cao F,Lane S,Raniga PP,et al.The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans[J].Mol Biol Cell,2006,17(1):295-307.
[47] Du H,Guan G,Xie J,et al.The transcription factor Flo8 mediates CO₂ sensing in the human fungal pathogen Candida albicans[J].Mol Biol Cell,2012,23(14):2692-2701.