关键词: 卢立康唑, 特比萘芬, 股癣, 疗效, 随机对照双盲

Abstract:

Objective To observe and assessment of the efficacy and safety of luliconazole cream (1%) in patients with tinea cruris.Method Sixty patients positive for fungal elements on direct microscopy were equally and randomly divided into 2 groups:experimental group applying luliconazole cream (1%) once daily for 2 weeks,control group applying terbinafine cream (1%) once daily for 2 weeks.Efficacy was assessed on week 1,2,4,8 after initiation of treatment.Result 60 patients were eligible for the efficacy analysis.On week 1 after initiation of treatment,the clinical effective rate in the experimental group and control group was 40% VS 23.3%,the fungal clearance rate was 23.3% VS 20%.On week 2 after initiation of treatment,the clinical effective rate in the experimental group and control group was 80% VS 70%,the fungal clearance rate was 70% VS 63.3%.On week 6 after the end of treatment,the clinical effective rate in the experimental group and control group was 83.3% VS 70%,the fungal clearance rate was 80% VS 66.7%.Conclusion Luliconazole cream (1%) have strong ability in relieving signs and symptoms of patients and low recurrence rate.Luliconazole cream (1%) is effective and well tolerated in the treatment of tinea cruris.

Key words: luliconazle, terbinafine, tinea cruris, efficacy, randomized double-blind controlled