1%卢立康唑乳膏治疗念珠菌性包皮龟头炎多中心疗效观察

中国真菌学杂志　 2016, Vol. 11 　Issue (6): 381-384.

真菌病治疗上一篇

1%卢立康唑乳膏治疗念珠菌性包皮龟头炎多中心疗效观察

高方铭¹, 易江华², 叶兴东¹, 肖常青¹, 高爱莉¹, 刘玉梅¹, 戴向农¹

1. 广州医科大学皮肤病研究所广州市皮肤病防治所, 广州 510095;
2. 广州医科大学附属第三医院皮肤科, 广州 510145

收稿日期:2016-11-14 出版日期:2016-12-28 发布日期:2016-12-28
通讯作者: 叶兴东,E-mail:yxingdong@qq.com E-mail:yxingdong@qq.com
作者简介:高方铭,男(汉族),硕士研究生在读.E-mail:469427058@qq.com
基金资助:
中国中西医结合临床研究基金（CAIM-LLKZ-002）

A multicenter study on curative effect of 1% luliconazole cream in treatment of candidal balanoposthitis

GAO Fang-ming¹, YI Jiang-hua², YE Xing-dong¹, XIAO Chang-qing¹, GAO Ai-li¹, LIU Yu-mei¹, DAI Xiang-nong¹

1. Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China;
2. Department of Dermatology, The Affiliated Hospital of Guangzhou Medical University, Guangzhou 510145, China

Received:2016-11-14 Online:2016-12-28 Published:2016-12-28

摘要/Abstract

摘要：

目的观察1%卢立康唑乳膏治疗念珠菌性包皮龟头炎临床疗效及安全性。方法 70例患者随机分为两组，治疗组38例，对照组32例，分别外涂1%卢立康唑乳膏与2%酮康唑乳膏，每日1次，治疗1周及2周后根据临床症状、体征及真菌学检查判定疗效，并根据不良反应评价其安全性。结果卢立康唑乳膏组1周真菌学清除率高于酮康唑乳膏组，差异有统计学意义（P<0.05），而临床疗效及2周真菌学清除率，两组差异无统计学意义（P>0.05）；两组在临床疗效、症状及体征评分方面未见明显差异（P>0.05）。结论 1%卢立康唑乳膏治疗念珠菌性包皮龟头炎具有良好的疗效及安全性，值得临床推广。

关键词: 卢立康唑, 念珠菌性包皮龟头炎, 疗效观察

Abstract:

Objective To investigate the curative efficiency and safety of luliconazole 1% cream in treating candidal balanoposthitis.Methods A total of 70 outpatients from department of Dermatology & STD were randomly divided into two groups.Among them,38 were given luliconazole 1% cream once a day (study group) while the others were given ketoconazole cream once a day (control group).The effect was evaluated based on scores of relief for symptoms,skin signs,and mycology inspection,while the safety was evaluated according to the side effects.Results The mycological clearance rate of 1% luliconazole cream was significantly higher than that of 2% ketoconazole cream one week after treatment (P<0.05),but there was no significant difference of clinical efficacy and mycological clearance rate between the two groups two weeks after treatment (P>0.05).No significant difference was observed between the two groups in evaluation scores of clinical effect,symptom and skin sign aspects.Conclusion The curative effect and safety for 1% luliconazole cream were comparable to those of 2% ketoconazole cream in treating candidal balanoposthitis.It is worth popularizing and applying clinically.

Key words: luliconazole, candidal balanoposthitis, curative effect

中图分类号:

R519.3

高方铭, 易江华, 叶兴东, 肖常青, 高爱莉, 刘玉梅, 戴向农. 1%卢立康唑乳膏治疗念珠菌性包皮龟头炎多中心疗效观察[J]. 中国真菌学杂志, 2016, 11(6): 381-384.

GAO Fang-ming, YI Jiang-hua, YE Xing-dong, XIAO Chang-qing, GAO Ai-li, LIU Yu-mei, DAI Xiang-nong. A multicenter study on curative effect of 1% luliconazole cream in treatment of candidal balanoposthitis[J]. Chinese Journal of Mycology, 2016, 11(6): 381-384.

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1%卢立康唑乳膏治疗念珠菌性包皮龟头炎多中心疗效观察

A multicenter study on curative effect of 1% luliconazole cream in treatment of candidal balanoposthitis

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