申克孢子丝菌基因分型的研究现状与展望

摘要/Abstract

摘要：

申克孢子丝菌以往被认为单一菌种，呈全球性分布。然而不同区域来源的菌株，在药物敏感性、致病力等方面差异较大。RAPD、RFLP等多种分子生物学技术曾被用于该菌基因分型的探讨。近年来，以CAL基因结合菌株表型的分类方法，已成为申克孢子丝菌复合体公认的划分方法。本文将对申克孢子丝菌的基因分型方法进行综述，并着重阐述CAL基因分型的研究进展。

关键词: 申克孢子丝菌, 孢子丝菌病, 基因分型, 钙调蛋白基因

Abstract:

Sporothrix schenckii sensu lato,previously considered to be a single species,has a worldwide distribution.Nevertheless,strains from different geographical regions differ greatly in their pathogenicity and susceptibility to different drugs.A wide variety of molecular techniques such as random amplified polymorphic DNA (RAPD),restriction fragment length polymorphism (RFLP) have been investigated for genotyping of the fungi.In recent years,classification methods based on calmodulin (CAL) gene and phenotypic features have been accepted to distinguish isolates in the Sporothrix schenckii complex.The genotyping methods of Sporothrix schenckii s.l. have been summarized in this article and focus on the research progress of CAL gene.

Key words: Sporothrix schenckii, sporotrichosis, genotype, calmodulin gene

中图分类号:

R379.9

赵莉佩, 崔岩, 李珊山. 申克孢子丝菌基因分型的研究现状与展望[J]. 中国真菌学杂志, 2016, 11(5): 316-320.

ZHAO Li-pei, CUI Yan, LI Shan-shan. Research status and prospect of genotyping of Sporothrix schenckii sensu lato[J]. Chinese Journal of Mycology, 2016, 11(5): 316-320.

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