伏立康唑首次成功治疗难治性面部Majocchi肉芽肿1例并文献复习

中国真菌学杂志　 2016, Vol. 11 　Issue (5): 265-268.

伏立康唑首次成功治疗难治性面部Majocchi肉芽肿1例并文献复习

颜文良¹, 胡文星¹, 刘芳¹, 刘海波¹, 孔庆涛¹, 张敏¹, 沈永年², 吕桂霞², 桑红¹

1. 南京军区南京总医院皮肤科, 南京 210002;
2. 中国医学科学院皮肤病医院, 南京 210042

收稿日期:2016-02-18 出版日期:2016-10-28 发布日期:2016-10-28
通讯作者: 桑红,E-mail:shzwqzsl@163.com E-mail:shzwqzsl@163.com
作者简介:颜文良,男(汉族),硕士,住院医师.E-mail:fdabing128@163.com

First successful treatment of refractory facial Majocchi granuloma with voriconazole and literature reviewed

YAN Wen-liang¹, HU Wen-xing¹, LIU Fang¹, LIU Hai-bo¹, KONG Qing-tao¹, ZHANG Min¹, SHEN Yong-nian², LV Gui-xia², SANG Hong¹

1. Department of Dermatology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;
2. Hospital of Dermatology, Chinese Academy of Medical Sciences, Nanjing 210042, China

Received:2016-02-18 Online:2016-10-28 Published:2016-10-28

摘要/Abstract

摘要：

目的首次报道伏立康唑成功治疗1例红色毛癣菌引起的顽固性面部Majocchi肉芽肿，分析患者的临床表现、病理特点、真菌学检查及分子生物学鉴定结果，并总结英文报道病例。方法患者男，50岁，因面部浸润性红斑溃疡5 a就诊，取患处皮损进行组织病理学检查、真菌学检查、药物敏感试验及PCR检测。结果诊断：红色毛癣菌致面部Majocchi肉芽肿。治疗：伏立康唑静脉治疗2周改伏立康唑片剂口服，治疗4个月后患者原有皮损基本消退，真菌学阴性，无不良反应。结论 Majocchi肉芽肿临床罕见，复杂难治，疗程长，易反复，严重影响患者生活质量，我们首次应用伏立康唑成功治疗顽固性Majocchi肉芽肿，为临床治疗难治性Majocchi肉芽肿提供新的诊疗经验。

关键词: Majocchi肉芽肿, 红色毛癣菌, 伏立康唑

Abstract:

Objective Reported one case of Majocchi's granuloma caused by Trichophyton rubrum which was successfully treated with voriconazole.Analysized clinical manifestations,pathological features,mycological examination and identification results of molecular biology,and summaried cases reported in English.Methods A 50-year-old man had infiltrated erythematous plaque on face for five years.Mycological examination,histopathological examination,rDNA ITS sequence analysis and drug susceptibility testing were performed on the specimens from skin biopsy.Results The patient was diagnosed as Majocchis's granuloma caused by Trichophyton rubrum.He was treated with voriconazole,with a complete resolution of dermatosis,negative of mycology and no adverse reactions.Conclusions Majocchi's granuloma is rare,often refractory and recurrent,seriously affecting the life quality of patients.We first apply voriconazole in the treatment of a refractory Majocchi's granuloma with conspicuous resolution of dermatosis which provide new experience in treatment of refractory Majocchi's granuloma.

Key words: Majocchi's granuloma, Trichophyton rubrum, voriconazole

中图分类号:

R756.6

颜文良, 胡文星, 刘芳, 刘海波, 孔庆涛, 张敏, 沈永年, 吕桂霞, 桑红. 伏立康唑首次成功治疗难治性面部Majocchi肉芽肿1例并文献复习[J]. 中国真菌学杂志, 2016, 11(5): 265-268.

YAN Wen-liang, HU Wen-xing, LIU Fang, LIU Hai-bo, KONG Qing-tao, ZHANG Min, SHEN Yong-nian, LV Gui-xia, SANG Hong. First successful treatment of refractory facial Majocchi granuloma with voriconazole and literature reviewed[J]. Chinese Journal of Mycology, 2016, 11(5): 265-268.

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