[1] Lortholary O,Improvisi L,Nicolas M,et al.Fungemia during murine cryptococcosis sheds some light on pathophysiology[J].Med Mycol,1999,37(3):169-174.
[2] Huston SM,Mody CH.Cryptococcosis:an emerging respiratory mycosis[J].Clin Chest Med,2009,30(2):253-264.
[3] Park BJ,Wannemuehler KA,Marston BJ,et al.Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS[J].Aids,2009,23(4):525-530.
[4] Chang YC,Stins MF,McCaffery MJ,et al.Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier[J].Infect Immun,2004,72(9):4985-4995.
[5] Chen SH,Stins MF,Huang SH,et al.Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells[J].J Med Microbiol,2003,52(Pt11):961-970.
[6] Charlier C,Chrrtien F,Baudrimont M,et al.Capsule structure changes associated Cryptococcus neoformans crossing of the blood-brain barrier[J].Am J Pathol,2005,166(2):421-432.
[7] Cox GM,Mukherjee J,Cole GT,et al.Urease as a virulence factor in experimental cryptococcosis[J].Infect Immun,2000,68(2):443-448.
[8] Olszewski MA,Noverr MC,Chen GH,et al.Urease expression by Cryptococcus neoforrns promotes microvascular sequestration,thereby enhancing central nervoussystem invasion[J].Am J Pathol,2004,164(5):1761-1771.
[9] Chen SC,Wright LC,Santangelo RT,et al.Identification of extracellular phospholipase B,lysophospholipase,and acyltransferase produced by Cryptococcus neoformans[J].Infect Immun,1997,65(2):405-411.
[10] Noverr MC,Cox GM,Perfect JR,et al.Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production[J].Infect Immun,2003,71(3):1538-1547.
[11] Tucker SC,Casadevall A.Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm[J].Proc Natl Acad Sci USA,2002,99(5):3165-3170.
[12] Levitz SM,Nong SH,Seetoo KF,et al.Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages[J].Infect Immun,1999,67(2):885-890.
[13] Charlier C,Nielsen K,Daou S,et al.Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans[J].Infect Immun,2009,77(1):120-127.
[14] Santangelo R,Zoellner H,Sorrell T,et al.Role of extracellular phospholipases and mononuclear phagocytes in dissemination of cryptococcosis in a murine model[J].Infect Immun,2004,72(4):2229-2239.
[15] Shi M,Li SS,Zheng C,et al.Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain[J].J Clin Invest,2010,120(5):1683-1693.
[16] Jong A,Wu CH,Chen HM,et al.Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection[J].Eukaryotic cell,2007,6(8):1486-1496.
[17] Jong A,Wu CH,Shackleford GM,et al.Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells[J].Cell Microbiol,2008,10(6):1313-1326.
[18] Long M,Huang SH,Wu CH,et al.Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells[J].J Biomed Sci,2012,19:19.
[19] Huang SH,Long M,Wu CH,et al.Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3)[J].J Biol Chem,2011,286(40):34761-34769.
[20] Levitz SM,Nong SH,Seetoo KF,et al.Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages[J].Infect Immun,1999,67(2):885-890.
[21] Stie J,Bruni G,Fox D.Surface-associated plasminogen binding of Cryptococcus neoformans promotes extracellular matrix invasion[J].PloS one,2009,4(6):e5780.
[22] Lahteenmaki K,Edelman S,Korhonen TK.Bacterial metastasis:the host plasminogen system in bacterial invasion[J].Trends Microbiol,2005,13(2):79-85.
[23] Stie J,Fox D.Blood-brain barrier invasion by Cryptococcus neoformans is enhanced by functional interactions with plasmin[J].Microbiology,2012,158(Pt 1):240-258.
[24] Stie J,Fox D.Induction of Brain Microvascular Endothelial Cell Urokinase Expression by Cryptococcus neoformans Facilitates Blood-Brain Barrier Invasion[J].PLoS One,2012,7(11):e49402.
[25] Cuzner ML,Gveric D,Strand C,et al.The expression of tissue-type plasminogen activator,Matrix metalloproteinase and endogenous inhibitors in the central nenrous systerm in multiple sclerosis:comparison of stages in lesion evolution[J].J Neuropathol Exp Neurol,1996,55(12):1194-2004.
[26] Rosenberg GA,Cunningham LA,Wallace J,et al.Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain:acti'~ation of MMP-9 linked to stromelysin-1 and microglia in cell cultures[J].Brain Res,2001,893(1-2):104-112.
[27] Yu Q,Stamenkovic I.Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion[J].Genes Dev,1999,13(1):35-48.
[28] O'Connell PA,Surette AP,Liwski RS,et al.S100A10 regulates plasminogen-dependent macrophage invasion[J].Blood,2010,116(7):1136-1146.
[29] Mizoguchi H,Takuma K,Fukuzaki E,et al.Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice[J].Pharmacol Exp Ther,2009,331(1):14-22.