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中国真菌学杂志 2016, Vol. 11  Issue (2): 125-128.

综述 上一篇    

白念珠菌定植和肠源性感染模型研究进展

朱芳1, 何丽娟2, 黄鑫1, 安毛毛1, 姜远英1,2   

  1. 1. 同济大学附属第十人民医院, 上海 200072;
    2. 第二军医大学药学院, 上海 200433
  • 收稿日期:2015-07-24 出版日期:2016-04-28 发布日期:2016-04-28
  • 通讯作者: 姜远英,E-mail:jiangyy@tongji.edu.cn;安毛毛,E-mail:anmaomao@tongji.edu.cn E-mail:jiangyy@tongji.edu.cn;anmaomao@tongji.edu.cn
  • 作者简介:朱芳,女(汉族),硕士研究生在读.E-mail:fzhu2013@163.com
  • 基金资助:

    国家自然科学基金(81330083);科技部新药创制重大专项(2012ZX09103101-003)

The research progress on Candida albicans colonization and infection in the mice gastrointestinal tract

ZHU Fang1, HE Li-juan2, HUANG Xin1, AN Mao-mao1, JIANG Yuan-ying1,2   

  1. 1. Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China;
    2 School of Pharmacy, The Second Military Medical University, Shanghai 200433, China
  • Received:2015-07-24 Online:2016-04-28 Published:2016-04-28

摘要:

肠道共生白念珠菌是人体感染白念珠菌的重要来源。白念珠菌口胃接种到药物处理的成年小鼠,造成白念珠菌胃肠道定植和肠源性感染。此模型可以更加贴切地模拟白念珠菌人体胃肠道大量定植和肠源性感染。该文总结2000年以来白念珠菌定植和感染成年小鼠相关国内外文献,对白念珠菌胃肠道定植和肠源性感染模型新进展作一综述。

关键词: 白念珠菌, 定植, 侵袭性感染

Abstract:

Candida albicans was regarded as a commensal within the gut in humans and the gut had been considered as an important site for Candida albicans invasive infection.Antibiotic(s)-treated mice orally given Candida albicans could closely mimic the clinical manifestations, including gastrointestinal colonization and invasive infection.Immunosuppressants were required for the worse invasive infection.There we summarized the progress on the models of Candida albicans colonization and/or invasive infection in the gastrointestinal tract from related literatures since 2000.

Key words: Candida albicans, colonization, invasive infection

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