中国原发性皮肤毛霉病32例回顾性分析

摘要/Abstract

摘要：

目的总结我国报道的原发性皮肤毛霉病的临床资料,探讨其流行病学特点、易感因素、临床表现、致病菌种及治疗策略。方法检索文献并回顾分析我国32例皮肤毛霉病的临床资料。结果共检索全文27篇,病例32例。患者的平均发病年龄为39.97岁,男女比例为9:7,临床多表现为红斑、丘疹、结节,可缓慢扩展形成浸润性斑块伴溃疡坏死。诊断主要依赖于真菌学及组织病理学检查。治疗方法首选两性霉素B。结论原发性皮肤毛霉病是一种严重的毁容性深部真菌病,提高对本病的认识,有利于及早诊断和治疗,治疗首选两性霉素B。

关键词: 毛霉病, 皮肤毛霉病, 接合菌病

Abstract:

Objective To investigate and discuss the epidemiology, risk factors, clinical manifestations, pathomycete and treatment strategies for primary cutaneous mucormycosis.Methods Thirty-two cases of primary cutaneous mucormycosis were searched from the electrical database, and all the clinical information was collected and evaluated.Results Twenty-seven articles (32 cases) were included in the study.Median age was 39.97 years old, with a male predominance (M:F=9:7).The major clinical manifestations were local erythema, papula and nodule, which might spread into infiltrating plaque associated with ulceration and necrosis.Diagnosis was mainly dependent on mycologic and/or histopathological examination.Amphotericin B was the first-line antifungal drug for the disease.Conclusion Primary cutaneous mucormycosis is a rare severe devastatind deep fungal infection.Enhancing the understanding of its clinical characterisctics would contribute to the early diagnosis and timely treatment, and amphotericin B was the first-line choice.

Key words: mucormycosis, cutaneous mucormycosis, zygomycosis

中图分类号:

R519.8

吕红莉, 李澄, 李燕, 谭娟, 许人超, 汤劲辉. 中国原发性皮肤毛霉病32例回顾性分析[J]. 中国真菌学杂志, 2016, 11(2): 103-107.

LV Hong-li, LI Cheng, LI Yan, TAN Juan, XU Ren-chao, TANG Jin-hui. Retrospective analysis of primary cutaneous mucormycosis in China: a review of 32 cases[J]. Chinese Journal of Mycology, 2016, 11(2): 103-107.

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