新生隐球菌的模式识别受体及下游信号传导

中国真菌学杂志　 2016, Vol. 11 　Issue (1): 58-61.

新生隐球菌的模式识别受体及下游信号传导

李颖芳, 潘炜华

上海长征医院皮肤病与真菌病研究所全军真菌病重点实验室第二军医大学附属长征医院皮肤科, 上海 200003

收稿日期:2015-12-02 出版日期:2016-02-28 发布日期:2016-02-28
通讯作者: 潘炜华,E-mail:panweihua@medmail.com.cn E-mail:panweihua@medmail.com.cn
作者简介:李颖芳,女(汉族),硕士研究生在读.E-mail:liyingfang99@163.com
基金资助:
973项目(2013CB531606),国家自然基金(31270180)

Pattern regcognition receptors and signaling pathways in Cryptococcus neoformans

LI Ying-fang, PAN Wei-hua

Department of dermatology, Changzheng Hospital, Institute of dermatology and medical mycology, Changzheng Hospital, Key laboratory of molecular medical mycology, PLA key laboratory of medical mycology, Shanghai 200003

Received:2015-12-02 Online:2016-02-28 Published:2016-02-28

摘要/Abstract

摘要：

新生隐球菌感染机体后,经固有免疫细胞表面的模式识别受体(pattern recognition receptors,PRRs)识别病原相关分子模式(pathogen-associated molecular patterns,PAMPs),引发下游的信号传导通路,激活核因子NF-κB,进而启动固有免疫和适应性免疫,诱导相关炎症因子的生成,活化Th1、Th2、Th17等适应性免疫细胞,同时募集巨噬细胞吞噬清除隐球菌。目前对隐球菌模式识别受体的种类及功能仍有待探索,对其下游信号传导通路的研究需深入,充分研究模式识别受体和下游信号传导,将对隐球菌病的免疫调节和临床治疗提供思路。

关键词: 隐球菌, 模式识别受体(PRRs), 信号通路, 免疫

Abstract:

Pattern recognition receptors(PRRs) presented on the surface of host innate immune cells recognize the pathogen-associated molecular patterns(PAMPs) of Cryptococcus neoformans after the invasion,which will trigger downstream sinaling pathways and activate nuclear factor-kappa B(NF-κB) in immune cells,ultimately initiating innate and adaptive immunity,inducing the release of correlative inflammatory factors,activating adaptive immune cells such as Th1,Th2,Th17 cells,recruiting macrophage to eliminate Cryptococcus neoformans.Deep insights into PRRs and downstream pathways will contribute to obtain an overall understanding of immune adjustment and provide superior clinical therapys.

Key words: Cryptococcus neoformans, pattern recognition receptors(PRRs), signaling pathway, immunity

中图分类号:

R379.5

李颖芳, 潘炜华. 新生隐球菌的模式识别受体及下游信号传导[J]. 中国真菌学杂志, 2016, 11(1): 58-61.

LI Ying-fang, PAN Wei-hua. Pattern regcognition receptors and signaling pathways in Cryptococcus neoformans[J]. Chinese Journal of Mycology, 2016, 11(1): 58-61.

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