糖尿病患者合并接合菌病74例回顾性分析

中国真菌学杂志　 2016, Vol. 11 　Issue (1): 33-36.

糖尿病患者合并接合菌病74例回顾性分析

赵静宇¹, 方伟², 杨雅骊², 潘炜华², 廖万清², 汤依晨¹

1. 上海市皮肤病医院, 上海 200050;
2. 上海长征医院皮肤病与真菌病研究所全军真菌病重点实验室第二军医大学附属长征医院皮肤科, 上海 200003

收稿日期:2015-12-08 出版日期:2016-02-28 发布日期:2016-02-28
通讯作者: 汤依晨,E-mail:tangyichen@medmail.com.cn;廖万清,E-mail:liaowanqing@sohu.com E-mail:tangyichen@medmail.com.cn;liaowanqing@sohu.com
作者简介:赵静宇,女(满族),住院医师.E-mail:zjyhzq@126.com
基金资助:
国家973项目(2013CB531601);上海市自然科学基金(12ZR1454400,12JC1411000);国家自然科学基金青年项目(81501728)

Retrospective analysis of diabetics combined with zygomycosis in mainland China:a review of 74 cases

ZHAO Jing-yu¹, FANG Wei², YANG Ya-li², PAN Wei-hua², LIAO Wan-qing², TANG Yi-chen¹

1. Shanghai Dermatology Hospital, Shanghai 200050;
2. Shanghai key laboratory of Molecular Mycology, Department of Dermatology, Changzheng Hospital, Shanghai 200003

Received:2015-12-08 Online:2016-02-28 Published:2016-02-28

摘要/Abstract

摘要：

目的总结与探讨中国大陆地区近20余年间糖尿病合并接合菌病的流行病学特点及诊疗情况。方法检索分析重庆维普、CNKI系列数据库、万方数据库、中国医师协会全文期刊库及Pubmed等数据库中1990年以来中国大陆地区糖尿病合并接合菌病的临床相关文献资料。结果共检索文献57篇,病例74例。患者的平均发病年龄为49.8岁,男女比例为1.55:1,总死亡率为35.1%。其临床表现缺乏相对特异性,诊断主要依赖于真菌学及组织病理学检查。治疗方法首选两性霉素B,联合手术治疗较之单独抗真菌药物疗效更好。结论近年来中国大陆地区糖尿病合并接合菌病发病率较高。对糖尿病并高度怀疑接合菌病的患者,宜尽早启动抗真菌治疗,及时联合病灶切除者疗效更佳。

关键词: 接合菌病, 毛霉, 糖尿病, 中国

Abstract:

Objective To investigate the epidemiology and clinical characteristics of diabetics combined with zygomycosis in mainland China.Methods Literatures about diabetics combined with zygomycosis in China were collected from the electrical databases,such as CNKI,CJDF,VIP,Chinese physician full-text journals,and also Pubmed since 1990.Results Fifty-seven articles(74 cases) were included in the study.Median age was 49.8(range,16-77) years old,with a male predominance(M:F=1.55:1).Without specific clinical and radiographic features,its diagnosis was mainly dependent on mycologic and/or histopathological examination.Amphotericin B was the first-line antifungal drug for diabetics combined with zygomycosis,and better efficacy could be got if combined with surgical treatment.Conclusion In recent years,there is an increasing trend in the prevalence of diabetics combined with zygomycosis in mainland china.For highly suspected diabetics combined with zygomycosis,it's necessary to initiate early anti-fungal therapy,and combined surgical treatment may improve the outcome.

Key words: zygomycosis, Mucor, diabetics, China

中图分类号:

R519.8

赵静宇, 方伟, 杨雅骊, 潘炜华, 廖万清, 汤依晨. 糖尿病患者合并接合菌病74例回顾性分析[J]. 中国真菌学杂志, 2016, 11(1): 33-36.

ZHAO Jing-yu, FANG Wei, YANG Ya-li, PAN Wei-hua, LIAO Wan-qing, TANG Yi-chen. Retrospective analysis of diabetics combined with zygomycosis in mainland China:a review of 74 cases[J]. Chinese Journal of Mycology, 2016, 11(1): 33-36.

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