血清半乳甘露聚糖试验在诊断马尔尼菲青霉病中的应用

中国真菌学杂志　 2016, Vol. 11 　Issue (1): 16-19.

血清半乳甘露聚糖试验在诊断马尔尼菲青霉病中的应用

严汝帆¹, 李鑫垒², 郑冬燕¹, 林冰¹, 梁浩³, 曹存巍¹

1. 广西医科大学第一附属医院皮肤性病科广西艾滋病防治研究重点实验室, 南宁 530021;
2. 玉林市皮肤病防治医院, 玉林 537000;
3. 广西医科大学公共卫生学院流行病与卫生统计学教研室广西艾滋病防治研究重点实验室, 南宁 530021

收稿日期:2016-01-06 出版日期:2016-02-28 发布日期:2016-02-28
通讯作者: 曹存巍,E-mail:caocunwei@yeah.net E-mail:caocunwei@yeah.net
作者简介:严汝帆,女(汉族),硕士研究生在读.E-mail:yan7an@163.com
基金资助:
国家自然科学基金(81571971,81060128,81271804);广西自然科学基金(0991144,2012jjAA40175);广西卫生厅自筹课题(Z2007082)

The value of the galactomannan antigen assay in diagnosis Penicilliosis marneffei

YAN Ru-fan¹, LI Xin-lei², ZHENG Dong-yan¹, LIN Bing¹, LIANG Hao³, CAO Cun-wei¹

1. Department of Dermatology and Venereology, The First Affiliated hospital of Guangxi Medical University, Guangxi Key Laboratory of AIDS Prevention and Treatment, Nanning 530021, China;
2. Yulin Hospital of Dermatology, Yulin 537000, China;
3. Teaching and Research Department of Epidemiology and Health Statistics, Public Health of Guangxi Medical University & Guangxi Key Laboratory of AIDS Prevention and Treatment, Nanning 530021, China

Received:2016-01-06 Online:2016-02-28 Published:2016-02-28

摘要/Abstract

摘要：

目的评价血清半乳甘露聚糖(GM)试验在诊断马尔尼菲青霉感染(PSM)中的应用价值。方法收集2012~2015年间确诊PSM患者37例、其他真菌感染患者17例、健康志愿者30例血清,进行GM试验检测;同时评价其中4例PSM患者治疗前后GM值变化,计算诊断指标并分析评价。结果GM试验对PSM患者总体敏感度为78.38%,特异度为82.98%;其中对HIV阳性PSM患者敏感度为76.47%,特异度为97.87%;对HIV阴性PSM患者敏感度为75.00%,特异度为84.78%。4例随访的PSM患者经抗真菌药物治疗后,随着病情好转,GM水平逐渐下降。结论GM试验对PSM有一定的诊断价值,尤其对马尔尼菲青霉流行地区的HIV感染者,早期诊断PSM有重要意义。

关键词: 马尔尼菲青霉病, 半乳甘露聚糖试验, 诊断

Abstract:

Objective To evaluate the value of the galactomannan antigen assay in diagnosis Penicilliosis marneffei(PSM).Methods The serum samples were collected from 37 PSM patients,17 other fungal infection patients and 30 healthy volunteers.Platelia Aspergillus enzyme immunoassay kit was used.Results The sensitivities of total PSM patients,PSM patients with or without HIV infection were 78.38%,76.47%,75.00%,while their specificities were 82.98%,97.87%,84.78%,respectively.In 4 follow-up PSM patients,the GM decreased after anti-fungi treatment for 1 week as the clinical presentation improved.Conclusion This study showed that the GM test was significantly elevated for HIV patients with penicilliosis.The use of the GM antigen assay may facilitate earlier diagnosis of Penicillium marneffei infection for HIV-infected patients in areas of endemicity.

Key words: Penicilliosis marneffei, galactomannan, diagnosis

中图分类号:

R446.5

严汝帆, 李鑫垒, 郑冬燕, 林冰, 梁浩, 曹存巍. 血清半乳甘露聚糖试验在诊断马尔尼菲青霉病中的应用[J]. 中国真菌学杂志, 2016, 11(1): 16-19.

YAN Ru-fan, LI Xin-lei, ZHENG Dong-yan, LIN Bing, LIANG Hao, CAO Cun-wei. The value of the galactomannan antigen assay in diagnosis Penicilliosis marneffei[J]. Chinese Journal of Mycology, 2016, 11(1): 16-19.

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