硝酸舍他康唑乳膏治疗婴幼儿念珠菌性皮炎的疗效观察

中国真菌学杂志　 2015, Vol. 10 　Issue (2): 115-117.

硝酸舍他康唑乳膏治疗婴幼儿念珠菌性皮炎的疗效观察

蔡晴, 戴鹤骏, 高志琴, 杨虹, 任香玉, 张敏, 杨连娟

上海市皮肤病医院, 上海 200050

收稿日期:2014-12-09 出版日期:2015-04-28 发布日期:2015-04-28
通讯作者: 杨连娟,E-mail:lianjuan_yang@aliyun.com E-mail:lianjuan_yang@aliyun.com
作者简介:蔡晴,女(汉族),博士,医师.E-mail:caiqingmail@163.com

The efficacy and safety of sertaconazole cream on infant dermatitis candidiasis

CAI Qing, DAI He-jun, GAO Zhiqing, YANG Hong, REN Xiang-yu, ZHANG Min, YANG Lian-juan

Shanghai Dermatology hospital, Department of Mycology, Shanghai 200050

Received:2014-12-09 Online:2015-04-28 Published:2015-04-28

摘要/Abstract

摘要：

目的观察硝酸舍他康唑乳膏治疗婴幼儿念珠菌性皮炎的临床疗效和安全性。方法入选26例0~3岁念珠菌性皮炎的患儿,均经临床表现及真菌学检查确诊,外用硝酸舍他康唑乳膏2次/d,连续7~14 d,观察其临床疗效及治疗前后真菌学变化。结果 26例患儿治疗7 d临床评分均值由6分下降至1.35分,下降幅度超过75%。治疗7 d临床痊愈率为57.69%,有效率为92.3%,真菌学阴转率为88.46%;14 d临床痊愈率为92.3%,真菌学阴转率为92.3%。停药后第14天随访痊愈患儿91.67%未见复发。仅1例患儿出现不良反应。结论硝酸舍他康唑乳膏治疗婴幼儿皮肤念珠菌病安全、有效,不良反应少,值得临床推广。

关键词: 硝酸舍他康唑, 念珠菌性皮炎, 抗真菌药物, 婴幼儿

Abstract:

Objective To investigate the clinical efficacy and safety of sertaconazole cream on infant suffering from dermatitis candidiasis.Method Twenty-six patients with clinical and mycological diagnosis of dermatitis candidiasis were enrolled.Patients were treated with twice daily applications of sertaconazole cream for 14 days and were followed-up for 2 further weeks.Results Twenty-two Candida albicans and four non-Candida albicans were isolated in twenty-six infants.The treatment evaluation after 7 days treatment showed that more than 75% of average signs decreased from 6 to 1.35.There was a total clinical cure in 57.69%,improvement in 92.3% and mycological cure in 88.46% after 7 days treatment.At the time of 14 days follow-up,there was a total clinical and mycological cure in 92.3%.91.67% cure infants had not recurred at the end of the follow-up period.There was side effect in only one patient.Conclusions Based on its safety and effectiveness,sertaconazole cream may be considered a new alternative for infant dermatitis candidiasis treatment.

Key words: Sertaconazole, dermatitis candidiasis, antifungal, infant

中图分类号:

R756.5

蔡晴, 戴鹤骏, 高志琴, 杨虹, 任香玉, 张敏, 杨连娟. 硝酸舍他康唑乳膏治疗婴幼儿念珠菌性皮炎的疗效观察[J]. 中国真菌学杂志, 2015, 10(2): 115-117.

CAI Qing, DAI He-jun, GAO Zhiqing, YANG Hong, REN Xiang-yu, ZHANG Min, YANG Lian-juan. The efficacy and safety of sertaconazole cream on infant dermatitis candidiasis[J]. Chinese Journal of Mycology, 2015, 10(2): 115-117.

参考文献

[1] Pfaller MA,Sutton DA.Review of in vitro activity of sertaconazole nitrate in the treatment of superficial fungal infections
[J].Diagn Microbiol Infect Dis,2006,56(2):147-152.

[2] Choudhary S,Bisati S,Singh A,et al.Efficacy and safety of terbinafine hydrochloride 1% cream vs.sertaconazole nitrate 2% cream in tinea corporis and tinea cruris:a comparative therapeutic trial
[J].Indian J Dermatol,2013,58(6):457-460.

[3] 赵辩.中国临床皮肤病学
[M].4版.南京:江苏科学技术出版社,2010:575.

[4] Carrillo-Muoz AJ,Torres-Rodriguez JM.In-vitro antifungal activity of sertaconazole,econazole,and bifonazole against Candida spp
[J].J Antimicrob Chemother,1995,36(4):713-716.

[5] Carrillo-Muoz AJ,Tur-Tur C.Comparative study of antifungal activity of sertaconazole,terbinafine,and bifonazole against clinical isolates of Candida spp.Cryptococcus neoformans and dermatophytes
[J].Chemotherapy,1997,43(6):387–392.

[6] Drouhet E,Dupont B.In vitro antifungal activity of sertaconazole
[J].Arzneimittelforschung,1992,42(5a):705-710.

[7] Palacin C,Tarrago C,Agut J,et al.In vitro activity of sertaconazole,fluconazole,ketoconazole,fenticonazole,clotrimazole and itraconazole against pathogenic vaginal yeast isolates
[J].Methods Find Exp Clin Pharmacol,2001,23 (2):61-64.

[8] 蔡晴,王乐,曾荣,等.卢立康唑等七种咪唑类抗真菌药物对常见念珠菌的体外活性检测
[J].中华皮肤科杂志,2012,45(8):538-540.

[9] Agut J,Palacín C,Sacristán A,et al.Inhibition of ergosterol synthesis by sertaconazole in Candida albicans
[J].Arzneimittelforschung,1992,42(5A):718-720.

[10] Agut J,Palacín C,Salgado J,et al.Direct membrane damaging effect of sertaconazole on Candida albicans as a mechanism of its fungicidal activity
[J].Arzneimittelforschung,1992,42 (5A):721-724.

[11] Borelli C,Klovekorn G,Ernst TM,et al.Comparative study of 2% sertaconazole solution and cream formulations in patients with tinea corporis,tinea pedis interdigitalis,or a corresponding candidosis
[J].Am J Clin Dermatol,2007,8 (6):371-378.

[12] 杨连娟,高志琴,龚伟明,等.念珠菌性包皮龟头炎56例临床分析
[J].中国真菌学杂志,2013,8(2):87-89.

[13] Dellenbach P,Thomas JL,Guerin V,et al.Topical treatment of vaginal candidosis with sertaconazole and econazole sustained-release suppositories
[J].Int J Gynaecol Obstet,2000,71(Suppl 1):S47-52.

[14] 姚志荣,凌波,姜嫒芳,等.儿童皮肤念珠菌病的临床研究
[J].中华皮肤科杂志,2006,39(2):108-109.

[15] 吴启富.硝酸舍他康唑乳膏治疗儿童皮肤念珠菌病50例
[J].中国真菌学杂志,2012,7(2):106-108.