树突状细胞在抗真菌感染免疫中的作用

摘要/Abstract

摘要： 近年来,随着广谱抗生素、抗肿瘤药物和免疫抑制剂等药物的广泛使用,免疫功能降低患者数量的增加,侵袭性真菌感染性疾病的发病率逐年升高.树突状细胞 (Dendritic Cells,DCs)是已知功能最强的专职抗原提呈细胞,作为宿主固有免疫和适应性免疫的联系枢纽,DCs在病原微生物抗原的识别与呈递过程中发挥核心作用.研究证明,DCs可通过其细胞表面的多种受体有效识别病原真菌的抗原,并在诱导宿主免疫应答过程中发挥重要作用.本文将对树突状细胞分类及其在抗真菌感染免疫中的识别作用进行系统叙述.

关键词: 树突状细胞, 真菌感染, 免疫应答

Abstract: The number of life-threatening fungal infections has skyrocketed recently as a result of the abused of antibiotics,chemotherapy drugs and immunosuppressive drugs,as well as the increased immunocompromised patients.Dendritic cells(DCs)are the most powerful antigen-presenting cells.As the bridge between the innate and adaptive immune system,DCs play a central role in recognizing a variety of pathogens and presenting antigens.Many investigations demonstrate that DCs can effectively recognize fungal pathogens through several receptors on the cellular surface and promote the immune responses against invasive fungi.Here,we describe the characteristics of the various DCs subsets,the way of DC recognizing fungi,and their functions in immunity against fungal pathogens.

Key words: dendritic cells, fungal infection, immune response

中图分类号:

R519

王瑞丽, 廖勇, 敖俊红. 树突状细胞在抗真菌感染免疫中的作用[J]. 中国真菌学杂志, 2015, 10(1): 39-43,21.

WANG Rui-li, LIAO Yong, AO Jun-hong. Dendritic cells in anti-fungal immunity[J]. Chinese Journal of Mycology, 2015, 10(1): 39-43,21.

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