关键词: 播散性念珠菌病, 白念珠菌, 皮肤

Abstract: Objectives Disseminated candidiasis is a frequently fatal condition that is rising steadily in immunocompromised patients. We reported one case of disseminated candidiasis and reviewed currently available case reports on the cutaneous manifestations of disseminated candidiasis.Methods A 37-year-old woman with nodular on lower extremities as the initial presentation, involved of the lung and brain. She had focal segmental glomerulosclerosis (FSG) undergoing therapy of tacrolimus and prednisone for two years. Skin biopsies and culture of skin tissues, stools, urine and sputum were performed.Results With microbiological evidence of Candida albicans in skin tissue and kinds of excretions except cerebrospinal fluid and blood. Chest CT showed bilateral patchy infiltration. She was diagnosed as disseminated candidiasis and had anti-fungal therapy. A significant improvement of clinical symptoms and resolution of pulmonary were found in following days. But she had diffuse brain dissemination after interruption of antifungal treatment by herself.Conclusions Although widespread organ involvement is characteristic of disseminated candidiasis, reports of skin lesions are rare. Early cultures and biopsies resulted in early diagnosis, which prompted proper antifungal therapy and a positive outcome.

Key words: disseminated candidiasis, Candida albicans, cutanous