P2X7受体与炎性细胞因子

摘要/Abstract

摘要： P2X7受体是嘌呤受体中功能独特的一个亚型，为ATP控制的离子通道，在单核细胞、巨噬细胞、中性粒细胞中高表达，被ATP激活后导致K⁺外流和Ca²⁺内流、非选择性膜孔形成，启动一系列信号途径如炎症小体NALP3的活化，丝裂原蛋白激酶途径激活NF-κB增强炎性细胞因子转录，ROS和氮介质的产生，介导IL-1β、IL-6、IL-18、TNF-α、MIP-2、CCL2、HMGB1等多种炎性细胞因子的释放，参与炎症的发生发展，与真菌感染及阿尔茨海默病、类风湿性关节炎、哮喘等炎症性疾病密切相关。

关键词: P2X7受体, 炎性细胞因子, NALP3, MIP-2, HMGB1, 真菌

Abstract: P2X7 receptor is a special subtype of purine receptors, it functions as the ion channel which controlled by ATP. It has high expression on monocytes, macrophages and neutrophils. Its activation will result in Ca²⁺ inflow, K⁺ outflow, non-selective membrane channel formation, and will launch a series of signaling pathway including NALP3 formation, inflammatory cytokines transcription activated by NF-κB through mitogen-activated protein kinase, the production of ROS and nitrogen medium, and will mediate the release of many inflammatory cytokines such as IL-1β, IL-6, IL-18, TNF-α, MIP-2, CCL2 and HMGB1, and will take part in the development of inflammation, which is closely related to inflammatory disease including alzheimer's disease, rheumatoid arthritis and asthma and fungal infection.

Key words: P2X7 receptor, inflammation cytokine, NALP3, MIP-2, HMGB1, fungus

中图分类号:

R364.5

习德娥, 韩莉, 卢建明. P2X7受体与炎性细胞因子[J]. 中国真菌学杂志, 2014, 9(4): 252-256.

XI De-e, HAN Li,LU Jian-ming. P2X7 receptor and inflammation cytokine[J]. Chinese Journal of Mycology, 2014, 9(4): 252-256.

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