关键词: 两性霉素B, 侵袭性真菌感染, 疗效, 不良反应

Abstract:

Objective To analysis the therapeutic afficacy and adverse reactions of domestic amphotericin B on pulmonary invasive fungal infection in ICU.Methods Domestic amphotericin B was injected with steady speed by an intravenous injection pump. A total of 98 cases with pulmonary invasive fungal infection in ICU were reviewed.Results The clinical efficacy of domestic amphotericin B on the proven, the probable and the possible patients with invasive fungal infection was 28.57%,58.33% and 84.81% (P<0.01). The fungus clearance of domestic amphotericin B on the proven, the probable and the possible patients was 28.57%,41.67% and 84.81% (P<0.01).The adverse reactions included shiver and fever (9.18%),skin rash (4.08%),phlebitis (1.02%),nausea and vomiting (6.12%),hypokalaemia (16.32%),hepatic damage (1.02%) and renal impairment (4.08%). The adverse reaction occurred lowest when the daily dose was 0.5~0.8 mg·Kg^-1·d^-1, but highest when the daily dose was 1.2~1.5 mg·Kg^-1·d^-1 (P<0.05).Conclusions Domestic amphotericin B is affirmed in the therapy for IFI in ICU patients with tolerable adverse reactions by intravenous injection continuously.

Key words: amphotericin B, invasive fungal infection, the therapeutic afficacy, adverse reaction