近平滑念珠菌引起真菌性膝关节炎：病例报告及文献回顾

中国真菌学杂志　 2014, Vol. 9 　Issue (3): 147-149,154.

近平滑念珠菌引起真菌性膝关节炎：病例报告及文献回顾

吕宏¹, 黄土林¹, 朱红梅²

1. 上海市开元骨科医院, 上海 200129;
2. 上海长征医院皮肤病与真菌病研究所全军真菌病重点实验室第二军医大学附属长征医院皮肤科, 上海 200003

收稿日期:2014-05-24 出版日期:2014-06-28 发布日期:2014-06-28
通讯作者: 朱红梅，E-mail：hmzhu_cn@163.com E-mail:hmzhu_cn@163.com
作者简介:吕宏，男（汉族），博士，主治医师.E-mail：lvhong@sohu.com

Fungal arthritis of the knee caused by Candida parapsilosis：case report and literature review

LV Hong¹, HUANG Tu-lin¹, ZHU Hong-mei²

1. Shanghai Kaiyuan Orthopedics Hospital, Shanghai 200129, China;
2. Department of dermatology, Changzheng Hospital, Institute of dermatology and medical mycology, Changzheng Hospital, Key laboratory of molecular medical mycology, PLA key laboratory of medical mycology, Shanghai 200003

Received:2014-05-24 Online:2014-06-28 Published:2014-06-28

摘要/Abstract

摘要：

报告1例由近平滑念珠菌引起的膝关节炎并进行相关骨关节真菌感染的文献回顾。患者，男，53岁，有糖尿病史及左侧腘窝皮肤浅表小肿瘤切除史，因左膝关节反复疼痛7 a，逐渐加重伴跛行6个月入院。临床表现为左膝关节明显红肿，影像学发现关节腔内滑膜增生，临近胫骨上端及股骨下端有灶性骨破坏、吸收，关节腔积液查见真菌，鉴定为近平滑念珠菌。经关节镜清理术及静脉用氟康唑治疗后症状改善，随访2 a无复发，已恢复日常活动。本文结合本例患者进行了骨关节真菌感染的相关文献复习，对骨关节感染的相关因素及治疗等内容进行了回顾，其结果对临床相关医生具有重要参考价值。

关键词: 膝, 关节炎, 近平滑念珠菌

Abstract:

We report a rare case of fungal arthritis of the knee caused by Candida parapsilosis in a 53-year-old male, who had a history of diabetes and a superficial benign neoplasm resection of the left popliteal fossa. This patient had experienced continued pain and swelling on the left knee joint in a period of 7 years, and couldn't move freely.Candida parapsilosis was isolated from the left knee joint effusion.This case had mycologic cure and symptom improvement by treating with both arthroscopic debridement and intravenous fluconazole. Fungal arthritis is an unusual infection. It might occur in immunocompromised patients or those who had received previous invasive procedures on the joint. But for this case, the diabetes and the previous local superficial resection of the left popliteal fossa might the high risk factors. The early mycological examination will help to improve the early diagnosis and treatment.

Key words: knee joint, arthritis, Candida parapsilosis

中图分类号:

R519.3

吕宏, 黄土林, 朱红梅. 近平滑念珠菌引起真菌性膝关节炎：病例报告及文献回顾[J]. 中国真菌学杂志, 2014, 9(3): 147-149,154.

LV Hong, HUANG Tu-lin, ZHU Hong-mei. Fungal arthritis of the knee caused by Candida parapsilosis：case report and literature review[J]. Chinese Journal of Mycology, 2014, 9(3): 147-149,154.

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